CONTENTS
概要
実施事業
研究報告
リンク
  長崎大学重点研究課題「骨格系の基盤研究拠点形成」
長崎大学歯学部歯周病基盤研究センター
 
 
研究報告
 
HOME＞研究報告＞2008年度「口腔環境制御研究」報告：大阪大学歯学部

２００８年度「口腔環境制御研究」報告： 大阪大学歯学部
 
先端機器情報学教室
  1. Kou Y, Inaba H, Kato T, Tagashira M, Honma D, Kanda T, Ohtake Y, and Amano A. 2008. Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols. J Periodontol 79(1): 174-180.
  2. Inaba H, Nakano K, Kato T, Nomura R, Kawai S, Kuboniwa M, Ishihara K, Ooshima T, and Amano A. 2008. Heterogenic virulence and related factors among clinical isolates of Porphyromonas gingivalis with type II fimbriae. Oral Microbiol Immunol 23(1): 29-35.
  3. Inaba H, Tagashira M, Honma D, Kanda T, Kou Y, Ohtake Y, and Amano A. 2008. Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen. Biol Pharm Bull 31(3): 527-530.
  4. Ohno T, Okahashi N, Morisaki I, and Amano A. 2008. Signaling pathways in osteoblast proinflammatory responses to infection by Porphyromonas gingivalis. Oral Microbiol Immunol 23(2): 96-104.
  5. Kato T, Tsuda T, Kawai S, Inaba H, Okahashi N, Shibata Y, Abiko Y, and Amano A. 2008. Porphyromonas gingivalis gingipains cause G1 arrest in osteoblastic/stromal cells. Oral Microbiol Immunol 23(2): 158-164.
  6. Murakami J, Kato T, Kawai S, Akiyama S, Amano A, and Morisaki I. 2008. Cellular motility of Down syndrome gingival fibroblasts is susceptible to impairment by Porphyromonas gingivalis invasion. J Periodontol 79(4): 721-727.
  7. Makiura N, Ojima M, Kou Y, Furuta N, Okahashi N, Shizukuishi S, and Amano A. 2008. Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. Oral Microbiol Immunol 23(4): 348-351.
  8. Tsuda K, Furuta N, Inaba H, Kawai S, Hanada K, Yoshimori T, and Amano A. 2008. Functional analysis of a5b1 _integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicle. Cell Struct
    Funct 33(1): 123-132.
  9. Inaba H, Hokamura K, Nakano K, Nomura R, Katayama K, Nakajima A, Yoshioka Y, Taniguchi K, Kamisaki Y, Ooshima T, Umemura K, Murad F, Wada K, and Amano A. 2009. Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen. FEBS Lett 583(1): 128-134.
Review articles
  1. Amano A, Murakami J, Akiyama S, and Morisaki I. 2008. Etiologic factors of early-onset periodontal disease in Down syndrome. Japanese Dental Science Rev 44(2): 118-127.
  2. Yoshimori T, and Amano A. 2009. Group A Streptococcus, a loser in the battle to autophagy. Current Topics Microbiol Immunol (in press).
  3. Amano A. 2009. Host-parasite interactions in periodontitis. Periodontology 2000 (in press).
  4. Amano A. 2009. Bacterial adhesins in periodontitis. Periodontology 2000 (in press).
  5. Amano A, Furuta N, and Tsuda K. 2009. Host membrane traffic to convey intracellular pathogens. Periodontology 2000 (in press).

保存歯科学教室
  1. Noiri Y, Katsumoto T, Azakami H, and Ebisu S. 2008. Effects of Er YAG laser irradiation on biofilm-forming bacteria associated with endodontic pathogens in vitro. J Endod 34(7): 826-829.
  2. Yabune Y, Imazato S, and Ebisu S. 2008. Assessment of inhibitory effects of fluoride-coated tubes on biofilm formation by using the in vitro unit waterline biofilm model. Appl Environ Microbiol 74(19): 5958-5964.
  3. Imazato S, Ohmori K, Russell RRB, McCabe JF, Momoi Y, and Maeda N. 2008. Determination of bactericidal activity of antibacterial monomer MDPB by a viability staining method. Dent Mater J 27(1): 145-148.
  4. Ikebe K, Imazato S, Izutani N, Matsuda K, Ebisu S, Nokubi T, and Walls AW. 2008. Association of salivary Streptococcus mutans levels determined by rapid detection system using monoclonal antibodies with prevalence of root surface caries. Am J Dent 21(5): 283-287.
  5. Nakajo K, Imazato S, Takahashi Y, Kiba W, Ebisu S, and Takahashi N. 2009. Fluoride released from glass-ionomer cement is responsible to inhibit acid production of caries-related oral streptococci. Dent Mater (in press).


小児歯科学教室
  1. Nakano K, Inaba H, Nomura R, Nemoto H, Takeuchi H, Yoshioka H, TodaK, Taniguchi K, Amano A, and Ooshima T. 2008. Distribution of Porphyromonas gingivalis fimA genotypes in cardiovascular specimens from Japanese patients. Oral Microbiol Immunol 23(2): 170-172.
  2. Nemoto H, Nakano K, Nomura R, and Ooshima T. 2008. Molecular characterization of Streptococcus mutans strains isolated from heart valve of infective endocarditis patient. J Med Microbiol 57(Pt7): 891-895.
  3. Matsumoto-Nakano M, Tsuji M, Amano A, and Ooshima T. 2008. Molecular interaction of alanine-rich and proline-rich regions of cell surface protein antigen c in Streptococcus mutans. Oral Microbiol Immunol 23(4): 265-270.
  4. Nakano K, Nomura R, Nemoto H, Lapirattanakul J, Taniguchi N, Grönroos L, Alaluusua S, and Ooshima T. 2008. Protein antigen in serotype k Streptococcus mutans clinical isolates. J Dent Res 87(10): 964-968.
  5. Nakano K, Miyamoto E, Tamura K, Nemoto H, Fujita K, Nomura R, and Ooshima T. 2008. Distribution of 10 periodontal bacterial species in children and adolescents over 7-year period. Oral Dis 14(7): 658-664.
  6. Lapirattanakul J, Nakano K, Nomura R, Hamada S, Nakagawa I, and Ooshima T. 2008. Demonstration of mother to child transmission of Streptococcus mutans using multilocus sequence typing. Caries Res 42(6): 466-474.
  7. Miyamoto E, Nakano K, Fujita K, Nomura R, Okawa R, Matsumoto M, and Ooshima T. 2009. Bacterial profiles of oral streptococcal and periodontal bacterial species in saliva specimens from Japanese subjects. Arch Oral Biol 54(4): 374-379.
  8. Nomura R, Nakano K, Nemoto H, Mukai T, Hata H, Toda K, Yoshioka H, Taniguchi K, Amano A, and Ooshima T. 2009. Molecular analyses of bacterial DNA in extirpated heart valves from patients with infective endocarditis. Oral Microbiol Immunol 24(1): 43-49.
  9. Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, Amano A, and Ooshima T. 2009. Detection of oral bacteria in cardiovascular specimens. Oral Microbiol Immunol 24(1): 64-68.
  10. Inagaki S, Matsumoto-Nakano M, Fujita K, Nagayama K, Funao J, Ooshima T. 2009. Effects of recombinase A deficiency on biofilm formation by Streptococcus mutans. Oral Microbiol Immunol 24(2): 104-108.
  11. Nomura R, Nakano K, Tanigichi N, Lapirattanakul J, Nemoto H, Grönroos L, Alaluusua S, and Ooshima T. (2009). Molecular and clinical analyses of gene encoding collagen-binding adhesin of Streptococcus mutans. J Med Microbiol 58(4): 469-475.
  12. Matsumoto-Nakano M, Tsuji M, Inagaki S, Fujita K, Nagayama K, Nomura R, Ooshima T. Contribution of cell surface protein antigen PAc of Streptococcus mutans to platelet aggregation. Oral Microbiol Immunol (in press).

口腔細菌学教室
  1. Terao Y, Mori Y, Yamaguchi M, Shimizu Y, Ooe K, Hamada S, and Kawabata S. 2008. Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. J Biol Chem 283(10): 6253-6260.
  2. Okamoto S, Terao Y, Tamura Y, Hamada S, and Kawabata S. 2008. Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes. FEMS Microbiol Lett 281(1): 73-80.
  3. Kunitomo E, Terao Y, Okamoto S, Rikimaru T, Hamada S, and Kawabata S. 2008. Molecular and biological characterization of histidine triad protein in group A streptococci. Microbes Infect 10(4): 414-423.
  4. Itsuki Y, Saeki M, Nakahara H, Egusa H, Irie Y, Terao Y, Kawabata S, Yatani H, and Kamisaki Y. 2008. Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. FEBS Lett. 582(16): 2365-2370.
  5. Yamaguchi M, Terao Y, Mori Y, Hamada S, and Kawabata S. 2008. PfbA, a nobel plasmin-and fibronectin-binding protein of Streptococcus pneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosis. J Biol Chem 283(52): 36272-36279.
  6. Okamoto S, Terao Y, Hasuike K, Hamada S, and Kawabata S. 2008. A novel streptococcal leucine zipper protein (Lzp) binds to human immunoglobulins. Biochem Biophys Res Commun 377 (4): 1128-1134.
  7. Nakata M, Köller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, and Kreikemeyer B. 2009. Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. Infect Immun. 77(1): 32-44.
  8. Terao Y, Isoda R, Murakami J, Hamada S, and Kawabata S. Molecular and biological characterization of novel gtf regulation-associated genes in Streptococcus mutans. Oral Microbiol Immunol (in press).

予防歯科学教室
  1. Capestany CA, Tribble GD, Maeda K, Demuth DR, and Lamont RJ. 2008. Role of the Clp system in stress tolerance, biofilm formation and intracellular invasion in Porphyromonas gingivalis. J Bacteriol 190(4): 1436-1446.
  2. Yilmaz O, Yao L, Maeda K, Rose TM, Lewis EL, Duman M, Lamont RJ, and Ojcius DM. 2008. ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X(7)-mediated host-cell apoptosis. Cell Microbiol 10(4): 863-875.
  3. Kuboniwa M, Hasegawa Y, Mao S, Shizukuishi S, Amano A, Lamont RJ, and Yilmaz ・ 2008. P. gingivalis accelerates gingival epithelial cell progression through the cell cycle. Microbes Infect 10(2): 122-128.
  4. Sekine S, Kataoka K, Fukuyama Y, Adachi Y, Davydova J, Yamamoto M, Kobayashi R, Fujihashi K, Suzuki H, Curiel DT, Shizukuishi S, McGhee JR, and Fujihashi K. 2008. A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature NALT dendritic cell migration. J Immunol 180(12): 8126-34.
  5. Suzuki H, Sekine S, Kataoka K, Pascual DW, Maddaloni M, Kobayashi R, Fujihashi K, Kozono H, McGhee JR, and Fujihashi K. 2008. Ovalbumin-protein s1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells. Gastroenterology 135 (3): 917-25.
  6. Fukuiwa T, Sekine S, Kobayashi R, Suzuki H, Kataoka K, Gilbert RS, Kurono Y, Boyaka PN, Krieg AM, McGhee JR, and Fujihashi K. 2008. A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity. Vaccine 26 (37): 4849-59.
  7. Maeda K, Tribble GD, Tucker CM, Anaya C, Shizukuishi S, Lewis JP, Demuth DR, and Lamont RJ. 2008. A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes. Mol Microbiol 69(5): 1153-64.
  8. Nagata H, Inagaki Y, Tanaka M, Ojima M, Kataoka K, Kuboniwa M, Nishida N, Shimizu K, Osawa K, and Shizukuishi S. 2008. Effect of eucalyptus extract chewing gum on periodontal health: A double-masked, randomized trial. J Periodontol 79(8): 1378-1385,
  9. Kuboniwa M, Amano A, Inaba H, Hashino E, and Shizukuishi S. 2009. Homotypic biofilm structure of Porphyromonas gingivalis is affected by FimA type variations. Oral Microbiol Immunol (in press).

口腔治療学教室
  1. Takedachi M, Qu D, Ebisuno Y, Oohara H, Joachims ML, McGee ST, Maeda E, McEver RP, Tanaka T, Miyasaka M, Murakami S, Krahn T, Blackburn MR, and Thompson LF. 2008. CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes. J Immunol 180(9): 6288-6296.

 
国立大学法人長崎大学