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長崎大学歯学部歯周病基盤研究センター
 
 
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HOME＞研究報告＞2010年度「口腔環境制御研究」報告：長崎大学歯学部

２０１０年度「口腔環境制御研究」報告： 長崎大学歯学部
 
口腔病原微生物学分野
  1. Yukitake H, Naito M, Sato K, Shoji M, Ohara N, Yoshimura M, Sakai E and Nakayama K.：Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis. Microbiol. Immunol. 55(3):141-153, 2011年03月
  2. Ito R, Ishihara K, Shoji M, Nakayama K, and Okuda K.：Hemmaglutinin/adhesion Domains of Porphyromonas gingivalis Play Key Roles in Coaggregation with Treponema denticola. FEMS Immunol. Med. Microbiol. 60(3):251-260, 2010年12月
  3. Shoji M, Yoshimura A, Yoshioka H, Takade A, Takuma Y, Yukitake H, Naito M, Hara Y, Yoshida S, and Nakayama K：Recombinant Porphyromonas gingivalis FimA preproprotein expressed in Escherichia coli is apidated and a mature or processed recombinant FimA protein forms a short filament in vitro. Can. J. Microbiol. 56(11):959-967, 2010年11月
  4. Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, and Sekimizu K.：Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae. J. Biol. Chem. 285(43):33338-33347, 2010年10月
  5. Yamaguchi M, Sato K, Yukitake H, Noiri Y, Ebisu S, and Nakayama K：Porphyromonas gingivalis mutant defective in a putative glycosyltransferase exhibits defective biosynthesis of polysaccharide portions of lipopolysaccharide, decreased gingipain activities, strong autoaggregation and increased biofilm formation. Infect. Immun. 78(9):3801-3812, 2010年09月
  6. Kondo Y, Ohara N, Sato K, Yoshimura M, Yukitake H, Naito M, Fujiwara T, and Nakayama K：Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis. Infect. Immun. 78(6):2846-2856, 2010年06月
  7. Shoji M, Shibata Y, Shiroza T, Yukitake H, Peng B, Chen Y-Y, Sato K, Naito M, Abiko Y, Reynolds EC, and Nakayama K：Characterization of hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis: its cellular distribution, thioredoxin activity and role in heme utilization. BMC Microbiol. 10:152 (online journal), 2010年05月
  8. Nhien NT, Huy NT, Naito M, Oida T, Uyen DT, Huang M, Kikuchi M, Harada S, Nakayama K, Hirayama K, Kamei K：Neutralization of toxic haem by Porphyromonas gingivalis haemoglobin receptor. J. Biochem. 147(3):317-325, 2010年05月

口腔病態薬理学分野
  1. Sato T, Nishishita K, Okada Y, Toda K.:The receptor potential of frog taste cells in response to cold and warm stimuli. Chem Senses. (2010) Jul;35(6):491-499.
  2. 2. Ikeda H, Sumita Y, Ikeda M, Ikeda H, Okumura T, Sakai E, Nishimura M, Asahina I. Engineering bone formation from human dental pulp- and periodontal ligament-derived cells. Ann Biomed Eng. 2011 Jan;39(1):26-34.
  3. Yukitake H, Naito M, Sato K, Shoji M, Ohara N, Yoshimura M, Sakai E, Nakayama K. Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis. Microbiol Immunol. 2011 Mar;55(3):141-153.

歯周病学分野
  1. Li X, Kato N, Mezawa M, Li Z, Wang Z, Yang L, Sasaki Y, Kaneko T, Takai H, Yoshimura A, Ogata Y: Transcriptional Regulation of Bone Sialoprotein Gene by Porphyromonas gingivalis Lipopolysaccharide. Journal of Cellular Biochemistry.110: 823–833, 2010.
  2. Shoji M, Yoshimura A, Yoshioka H, Takade A, Takuma Y, Yukitake H, Naito M, Hara Y, Yoshida S, Nakayama K: Recombinant Porphyromonas gingivalis FimA preproprotein expressed in Escherichia coli is a lipoprotein and recombinant FimA processed protein is auto-polymerized in vitro. Canadian Journal of Microbiology, 56(11): 959-967, 2010.
  3. Hayashi C, Madrigal AG, Liu X, Ukai T, Goswami S, Gudino CV, Gibson FCIII, Genco CA: Pathogen Mediated Inflammatory Atherosclerosis is Mediated in Part via TLR2 Induced Inflammatory Responses. J Innate Immun, 2(4): 334-343, 2010
  4. Ayon Haro E.R., Ukai T, Yokoyama M, Kishimoto T, Yoshinaga Y, Hara Y: Locally administered interferon-g accelerates lipopolysaccharide-induced osteoclastogenesis independent of immunohistological RANKL upregulation. Journal of Periodontal Research, 46(3):361-373, 2011
  5. Yokoyama M, Ukai T, Ayon Haro E.R., Kishimoto T, Yoshinaga Y, Hara Y: Membrane-bound CD40 Ligand on T cells from mice injected with lipopolysaccharide (LPS) accelerates LPS-induced osteoclastogenesis, Journal of Periodontal Research, in press
  6. 金子高士: 垂直性骨吸収への自家骨移植. DENTAL DIAMOND 35 (13): 94-96, 2010.
  7. 金子高士：歯周組織破壊に導く歯周病原細菌―宿主間相互作用の解明. 日歯周誌. ５３（１）：３－１２, ２０１１.


【受　賞】

  1. 口腔病原微生物学分野の佐藤啓子助教が「歯周病細菌P. gingivalisの新規のタンパク質分泌機構の発見」により平成２２年度歯科基礎医学会賞を受賞した。歯周病学分野の金子高士助教が「歯周組織破壊に導く歯周病原細菌-宿主間相互作用の解明」により平成２２年度日本歯周病学会学術賞を受賞した。


 
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