長崎大学大学院医歯薬学総合研究科細胞生物学分野

研究業績

HOME＞研究業績

2023年

  1. Matsushita Y, Liu J, Chu AKY, Tsutsumi-Arai C, Nagata M, Arai Y, Ono W, Yamamoto K, Saunders TL, Welch JD, Ono N. Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis. Nature Communications 14:2383, 2023
  2. Otani S, Ohnuma M, Ito K, Matsushita Y*. Cellular dynamics of distinct skeletal cells and the development of osteosarcoma. Frontiers in Endocrinology 14:1181204, 2023 (*corresponding author)
  3. Wu S, Ohba S, Matsushita Y*. Single-Cell RNA-Sequencing Reveals the Skeletal Cellular Dynamics in Bone Repair and Osteoporosis. International Journal of Molecular Sciences 24(12):9814, 2023 (*corresponding author)
  4. Matsushita Y, Manabe H, Ohyama T, Nakamura S, Nagata M, Ono W, Ono N. Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development. Journal of Biological Chemistry 299(6):104805, 2023
  5. Murayama M, Hirata H, Shiraki M, Iovanna JL, Yamaza T, Kukita T, Komori T, Moriishi T, Ueno M, Morimoto T, Mawatari M, Kukita A: Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice. Journal of Cellular Physiology 238(3):566-581. 2023

2022年

  1. Matsushita Y, Chu AKY, Tsutsumi-Arai C, Orikasa S, Nagata M, Wong SY, Welch JD, Ono W, Ono N. The fate of early perichondrial cells in developing bones. Nature Communications 13:7319, 2022
  2. Tsukagohi Y, Matsushita Y*. Bone regeneration: A message from clinical medicine and basic science. Clinical Anatomy 35(6):808-819, 2022 (*corresponding author)
  3. Iwanaga J, Matsushita Y, Watanabe K, Kageyama I, Tubbs RS, Ibaragi S. Clinical Anatomy Research Association in Oral and Maxillofacial Surgery. Journal of Craniofacial Surgery 33(3):942-944, 2022
  4. Matsushita Y, Ono W, Ono N. Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology. Biocell 46(5):1157-1162, 2022
  5. Matsushita Y, Ono W, Ono N. Toward marrow adipocytes: Adipogenic trajectory of the bone marrow stromal cell lineage. Frontiers in Endocrinology 13:882297, 2022
  6. Iwanaga J, Takeshita Y, Matsushita Y, Hur M.-S, Ibargi S, Tubbs RS. What are the retromolar and bifid/trifid mandibular canals as seen on cone-beam computed tomography? Revisiting classic gross anatomy of the inferior alveolar nerve and correcting terminology. Surgical and Radiologic Anatomy 44(1):147-156, 2022
  7. Iwanaga J, Matsushita Y, Ibaragi S, Tubbs RS. 3D anatomy of the ostiomeatal complex: A challenging concept in dentistry. Journal of Dental Education 86(S3):1739-1741, 2022
  8. Moriishi T and Komori T. Osteocytes: Their lacunocanalicular structure and mechanoresponses. International Journal of Molecular Sciences 23(8):4373, 2022
  9. Moriishi T, Ito T, Fukuyama R, Qin X, Komori H, Kaneko H, Matsuo Y, Yoshida N, Komori T. Sp7 transgenic mice with a markedly impaired lacunocanalicular network induced Sost and reduced bone mass by unloading. International Journal of Molecular Sciences 23(6):3173, 2022
  10. Ueda-Ichinose Y, Hotokezaka H, Miyazaki T, Moriishi T, Hotokezaka Y, Arizono K, Nakamura T, Yoshida N. Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats. The Angle Orthodontist in press, 2022
  11. Kitaura Y, Nakamura U, Awada C, Yamaguchi M, Kim M, Ikeda Y, Matsuo Y, Moriishi T, Sawase T, Chung UI, Hojo H, Ohba S: Orally administrable peptides derived from egg yolk promote skeletal repair and ameliorate degenerative skeletal disorders in mouse models. Regenerative Therapy 21:584-595, 2022
  12. Jiang Q, Qin X, Nagano K, Komori H, Matsuo Y, Taniuchi I, Ito K, Komori T: Different requirements of CBFB and RUNX2 in skeletal development among calvaria, limbs, vertebrae and ribs. International Journal of Molecular Sciences 23(21):13299, 2022

2021年

  1. Matsushita Y, Chu AKY, Ono W, Welch JD, Ono N. Intercellular interactions of an adipogenic CXCL12-expressing stromal cell subset in murine bone marrow. Journal of Bone and Mineral Research 36(6):1145-1158, 2021 * Selected to cover Image
  2. Hallett SA, Matsushita Y, Ono W, Sakagami N, Mizuhashi K, Tokavanich N, Nagata M, Zhou A, Hirai T, Kronenberg, HM, Ono N. Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment. eLife 10:e64513, 2021
  3. Matsushita Y, Ono W, Ono N. Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies: Quiescent mature skeletal cells can be activated in response to injury and robustly participate in bone regeneration through cellular plasticity. Bioessays 43(1):2000202, 2021
  4. Iwanaga J, Matsushita Y, Decater T, Ibaragi S, Tubbs RS. Mandibular canal vs. inferior alveolar canal: Evidence-based terminology analysis. Clinical Anatomy 34(2):209-217, 2021
  5. Iwanaga J, Kunisada Y, Masui M, Obata K, Takeshita Y, Sato K, Kikuta S, Abe Y, Matsushita Y, Kusukawa J, Tubbs RS, Ibaragi S. Comprehensive review of lower third molar management: A guide for improved informed consent. Clinical Anatomy 34(2):224-243, 2021
  6. Matsushita Y, Ono W, Ono N. Flow Cytometry-Based Analysis of the Mouse Bone Marrow Stromal and Perivascular Compartment. Methods in Molecular Biology 2308: 83-94, 2021
  7. Iwanaga J, Matsushita Y, Kishimoto N, Tubbs RS. The levels of evidence for a medical/dental lecture: A guide for lecture selection. Journal of Dental Education 85(S1):1099-1100, 2021
  8. Morita S, Moriishi T, Matsunaga S, Kitamura K, Abe SI, Yamaguchi A. Characteristic distribution of hematopoietic cells in bone marrow of xenopus laevis. The Bulletin of Tokyo Dental College 62(3):171-180, 2021

2020年

  1. Matsushita Y, Nagata M, Kozloff KM, Welch JD, Mizuhashi K, Tokavanich N, Hallett SA, Link DC, Nagasawa T, Ono W, Ono N. A Wnt-mediated conversion of the bone marrow stromal cell identity supports regeneration. Nature Communications 11(1):332, 2020 *Featured in a Nature Communications Editors’ Highlights
  2. Matsushita Y, Ono W, Ono N. Skeletal stem cells for bone development and repair: diversity matters. Current Osteoporosis Reports 18(3):189-198, 2020
  3. Matsushita Y, Ono W, Ono N. Growth plate skeletal stem cells and their transition from cartilage to bone. Bone 136:115359, 2020
  4. Tokavanich N, Gupta A, Nagata M, Takahashi A, Matsushita Y, Ruellas AC, Cevidanes LS, Maki K, Yamaguchi T, Ono N, Ono W. A three-dimensional analysis of primary failure of eruption in humans and mice. Oral Diseases 26(2):391-400, 2020
  5. Iwanaga J, Anand MK, Jain MN, Nagata M, Matsushita Y, Ibaragi S, Kusukawa J, Tubbs RS. Microsurgical anatomy of the superior wall of the mandibular canal and surrounding structures: suggestion for new classifications for dental implantology. Clinical Anatomy33(2):223-231, 2020
  6. Iwanaga J, Katafuchi M, Matsushita Y, Kato T, Horner K, Tubbs RS. Anatomy of the mandibular canal and surrounding structures: Part I: Morphology of the superior wall of the mandibular canal. Annals of Anatomy 232:151580, 2020
  7. Maekawa S, Nagata M, Matsushita Y, Tubbs RS, Iwanaga J. An unusual anatomical variation of the inferior alveolar nerve. Anatomy and Cell Biology 53(4):519-521, 2020
  8. Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLOS Genetics 16(11):e1009169, 2020
  9. Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, Miyazaki T, Liu W, Fukuyama R, Wang Y, Komori H, Qin X, Amizuka N, Komori T. Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. PLOS Genetics 16(5):e1008586, 2020
  10. Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, Miyazaki T, Liu W, Fukuyama R, Wang Y, Komori H, Qin X, Amizuka N, Komori T. Osteocalcin Is Necessary for the Alignment of Apatite Crystallites, but Not Glucose Metabolism, Testosterone Synthesis, or Muscle Mass. PLOS Genetics 16(5):e1008586, 2020

2019年

  1. Takahashi A, Nagata M, Gupta A, Matsushita Y, Yamaguchi T, Mizuhashi K, Maki K, Ruellas AC, Cevidanes LS, Kronenberg HM, Ono N, Ono W. Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption. Proceedings of the National Academy of Sciences of the United States of America 116(2):575-580, 2019
  2. Mizuhashi K, Nagata M, Matsushita Y, Ono W, Ono N. Growth plate borderline chondrocytes behave as transient mesenchymal precursor cells. Journal of Bone and Mineral Research 34(8):1387-1392, 2019
  3. Pepe-Mooney B, Dill MT, Alemany A, Ordovas-Montanes J, Matsushita Y, Rao A, Sen A, Miyazaki M, Anakk S, Dawson PA, Ono N, Shalek AK, Van Oudenaarden A, Camargo FD. Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration. Cell Stem Cell 25(1):23-38.e8. 2019

2018年

  1. Mizuhashi K, Ono W, Matsushita Y, Sakagami N, Takahashi A, Saunders TL, Nagasawa T, Kronenberg HM, Ono N. Resting zone of the growth plate houses a unique class of skeletal stem cells. Nature 563(7730):254-258, 2018
  2. Sakagami N, Matsushita Y, Syklawer-Howle S, Kronenberg HM, Ono W, Ono N. Msx2 marks spatially restricted populations of mesenchymal precursors. Journal of Dental Research 97(11):1260-1267, 2018
  3. Miyazaki T, T Baba T, Mori M, Komori T. Collapsin response mediator protein 1, a novel marker protein for differentiated odontoblasts. Acta Histochemica et Cytochemica 51(6):185-190, 2018

2017年

  1. Naruse T, Yamashita K, Yanamoto S, Rokutanda S, Matsushita Y, Sakamoto Y, Sakamoto H, Ikeda H, Ikeda T, Asahina I, Umeda M. Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence. Oncology Letters 13(5): 3487-3493, 2017
  2. Sakamoto K, Matsushita Y, Minamizato T, Katsuki Y, Katsube KI, Yamaguchi A. The Bone Regeneration Model and Primary Osteoblastic Cell Culture Used in the Analysis of Ccn3 Transgenic and Knockout Mice. Methods in Molecular Biology 1489: 309-324, 2017
  3. He P, Iwanaga J, Matsushita Y, Adeeb N, Topale N, Tubbs RS, Kusukawa J. A Comparative Review of Mandibular Orthognathic Surgeries with a Focus on Intraoral Vertico-sagittal Ramus Osteotomy. Cureus 9(12): e1924, 2017

2016年

  1. Matsushita Y, Nakakuki K, Kosugi M, Kurohara K, Harada K. Does Intraoral miniplate fixation have a good postoperative stability after sagittal splitting ramus osteotomy? : Comparison with intraoral bicortical screw fixation. Journal of Oral and Maxillofacial Surgery 74(1): 181-189, 2016
  2. Matsushita Y*, Fujita S, Yanamoto S, Yamada SI, Rokutanda S, Yamashita K, Ikeda T, Umeda M. Spindle cell variant of ameloblastic carcinoma: a case report and literature review. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 121(3): e54-e61, 2016 (*corresponding author)
  3. Matsushita Y*, Hayashida S, Morishita K, Sakamoto H, Naruse T, Sakamoto Y, Yamada SI, Yanamoto S, Fujita S, Ikeda T, Umeda M. Denosumab-associated osteonecrosis of the jaw affects osteoclasts formation and differentiation: Pathological features of two cases. Molecular and Clinical Oncology 4(2): 191-194, 2016 (*corresponding author)
  4. Sakamoto Y, Matsushita Y, Yamada S, Yanamoto S, Shiraishi T, Asahina I, Umeda M. Risk factors of distant metastasis in patients with squamous cell carcinoma of the oral cavity. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 121(5). 474-480, 2016
  5. Yamada S, Hayashida S, Yanamoto S, Naruse T, Matsushita Y, Uda A, Rokutanda S, Kakehashi H, Ikeda H, Asahina I, Umeda M. A new strategy for surgical intervention of bisphosphonate-related osteonecrosis of the jaw: a retrospective study. Acta Medica Nagasakiensia 60: 97-102, 2016
  6. Naruse T, Yanamoto S, Matsushita Y, Sakamoto Y, Morishita K, Ohba S, Shiraishi T, Yamada S, Asahina I, Umeda M. Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis. Molecular and Clinical Oncology 5(2): 246-252, 2016
  7. Yamada S, Yanamoto S, Naruse T, Matsushita Y, Takahashi H, Umeda M, Nemoto TK, Kurita H. Skp2 regulates the expression of MMP-2 and MMP-9, and enhances the invasion potential of oral squamous cell carcinoma. Pathology and Oncology Research 22(3): 625-632, 2016
  8. Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T. Overexpression of BCLXL in osteoblasts inhibits osteoblast apoptosis and increases bone volume and strength. Journal of Bone and Mineral Research 31(7):1366-80, 2016

2015年

  1. Matsushita Y*, Yanamoto S, Takahashi H, Yamada S, Naruse T, Sakamoto Y, Ikeda H, Shiraishi T, Fujita S, Ikeda T, Asahina I, Umeda M. A clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery 44(5): 543-548, 2015 (*corresponding author)
  2. Matsushita Y*, Yanamoto S, Yamada S, Mori H, Takahashi H, Naruse T, Ikeda H, Shiraishi T, Minamikawa T, Shibuya Y, Komori T, Asahina I, Umeda M. Correlation between degree of bone invasion and prognosis in carcinoma of the mandibular gingiva: soft tissue classification based on UICC classification. Journal of Oral and Maxillofacial Surgery, Medicine, Pathology 27(5): 631-636, 2015 (*corresponding author)
  3. Matsushita Y*, Fujita S, Kawasaki G, Hirota Y, Rokutanda S, Yamashita K, Yanamoto S, Ikeda T Umeda M. Granular cell ameloblastoma. Case report of a particular ameloblastoma histologically resembling oncocytoma. Pathology International 65(1): 43-47, 2015 (*corresponding author)
  4. Matsushita Y*, Fujita S, Kawasaki G, Rokutanda S, Yamashita K, Yanamoto S, Ikeda T, Umeda M. Reply to letter to the editor by Ide et al. Pathology International 65(10): 567, 2015 (*corresponding author)
  5. Naruse T, Yanamoto S, Yamada S, Rokutanda S, Kawakita A, Takahashi H, Matsushita Y, Hayashida S, Imayama N, Morishita K, Yamashita K, Kawasaki G, Umeda M. Lipomas of the Oral Cavity: Clinicopathological and Immunohistochemical Study of 24 cases and Review of the Literature. Indian Journal of Otolaryngology and Head and Neck Surgery 67(Suppl 1): 67-73, 2015
  6. Naruse T, Yanamoto S, Yamada SI, Takahashi T, Matsushita Y, Imayama N, Ikeda H, Shiraishi T, Fujita S, Ikeda T, Asahina I, Umeda. Immunohistochemical study of vascular endothelial growth factor‑C/vascular endothelial growth factor receptor‑3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis. Oncology Letters 10(4): 2027-2034, 2015
  7. Imayama N, Yamada SI, Yanamoto S, Naruse T, Matsushita Y, Takahashi H, Seki S, Fujita S, Ikeda T, Umeda M. FOXC2 Expression is Associated with Tumor Proliferation and Invasion Potential in Oral Tongue Squamous Cell Carcinoma. Pathology and Oncology Research 21(3): 783-791, 2015
  8. Sanuki T, Mishima G, Kurata S, Watanabe T, Kiriishi K, Tachi M, Ozaki Y, Okayasu I, Kawai M, Matsushita Y, Miura K, Ayuse T. Comparison of the hemodynamic effects of propofol and ketamine as anesthetic induction agents during high-dose remifentanil administration: a single-center retrospective comparative study. The Journal of Dental Anesthesia and Pain Medicine 15(3): 129-134, 2015
  9. Sakamoto Y, Yanamoto S, Matsushita Y, Yamada SI, Takahashi H, Fujita S, Ikeda T, Umeda M. Simultaneous triple primary malignant melanomas occurring in the buccal mucosa, upper gingiva, and tongue: A case report. Journal of Oral and Maxillofacial Surgery, Medicine, Pathology 27(4): 540-543, 2015
  10. Miyazaki T, Baba TT, Mori M, Moriishi T, Komori T. Microtubule-associated protein tau (Mapt) is expressed in terminally differentiated odontoblasts and severely down-regulated in morphologically disturbed odontoblasts of Runx2 transgenic mice. Cell and Tissue Research 361(2):457-466, 2015

2014年

  1. Yanamoto S, Yamada S, Takahashi H, Naruse T, Matsushita Y, Ikeda H, Shiraishi T, Seki S, Fujita S, Ikeda T, Asahina I, Umeda M. Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence. International Journal of Oncology 44(4):1153-1162, 2014
  2. Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T. Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation. PLOS ONE 9(1):e86629, 2014

2013年

  1. Matsushita Y, Sakamoto K, Tamamura Y, Shibata Y, Minamizato T, Kihara T, Ito M, Katsube K, Hiraoka S, Koseki H, Harada K, Yamaguchi A. CCN3 Protein Participates in Bone Regeneration as an Inhibitory Factor. The Journal of Biological Chemistry 288(27):19973-19985, 2013
  2. Miyazaki T, Mori M, Yoshida CA, Ito C, Yamatoya K, Moriishi T, Kawai Y, Komori H, Kawane T, Izumi S, Toshimori K, Komori T. Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia. Histochemistry and Cell Biology 139(2):339-354, 2013

2012年

  1. Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T. Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PLOS ONE 7(6):e40143, 2012
長崎大学
ページのトップへ戻る