長崎大学大学院医歯薬学総合研究科細胞生物学分野

研究業績

代表論文

*corresponding author

  1. Ohba S*: Hedgehog signaling in skeletal development: Roles of Indian hedgehog and the mode of its action. Int J Mol Sci21(18):6665, 2020
  2. Onodera S, Saito A, Hojo H, Nakamura T, Zujur D, Watanabe K, Morita N, Hasegawa D, Masaki H, Nakauchi H, Nomura T, Shibahara T, Yamaguchi A, Chung UI, Azuma T*, Ohba S*: Hedgehog activation regulates human osteoblastogenesis. Stem Cell Reports 15(1):125-139, 2020
  3. Hojo H, Ohba S*: Gene regulatory landscape in osteoblast differentiation. Bone 137:115458, 2020
  4. Hojo H, Ohba S* Insights into gene regulatory networks in chondrocytes. Int J Mol Sci 20(24):6324, 2019
  5. Zujur D, Kanke K, Lichtler AC, Hojo H, Chung UI, Ohba S*: Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions. Sci Adv 3(5):e1602875, 2017
  6. Hayashi K, Okamoto F, Hoshi S, Katashima T, Zujur D, Li X, Shibayama M, Gilbert EP, Chung UI, Ohba S, Oshika T, Sakai T*: Fast-forming hydrogel with ultralow polymeric content as an artificial vitreous body. Nat Biomed Eng 1:44, 2017
  7. Hojo H, McMahon AP, Ohba S*: An emerging regulatory landscape for skeletal development. Trends Genet 32(12):774-787, 2016
  8. Kashiwagi M, Hojo H, Kitaura Y, Maeda Y, Aini H, Takato T, Chung UI, Ohba S*: Local administration of a hedgehog agonist accelerates fracture healing in a mouse model. Biochem Biophys Res Commun 479(4):772-778, 2016
  9. Aini H, Itaka K*, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung UI, Ohba S*: Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep 6:18743, 2016
  10. Ohba S*: Hedgehog signaling in endochondral ossification. J Dev Biol 4(2):20, 2016
  11. He X†, Ohba S†, Hojo H, McMahon AP*: AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development 143(16):3012-3023, 2016 (†equal contribution)
  12. Hojo H, Ohba S, He X, Lai LP, McMahon AP*: Sp7/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification. Dev Cell 37(3):238-253, 2016
  13. Ohba S*†, He X†, Hojo H, McMahon AP*: Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte. Cell Rep 12(2):229-243, 2015 (†equal contribution)
  14. Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung UI, Ohba S*: The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open 1:e000068, 2015
  15. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S*: Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports 2(6):751-760, 2014
  16. Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S*: Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014
  17. Ohba S*, Chung UI: PTHrP action on skeletal development: a key for the controlled growth of endochondral bones. Clinc Rev Bone Miner Metab 12(3):130-141, 2014
  18. Yano F*, Ohba S, Hosaka Y, Saito T, Chung UI: Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73(11):2062-2064, 2014
  19. Zhang X†, Peterson KA, Liu XS, McMahon AP*, Ohba S†: Gene regulatory networks mediating canonical Wnt signal directed control of pluripotency and differentiation in embryo stem cells. Stem Cells 31(12):2667-2679, 2013 (†equal contribution)
  20. Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung UI, Ohba S*: Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34(22):5530-5537, 2013
  21. Hojo H*, Ohba S*, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI: Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288(14):9924-9932, 2013
  22. Komiyama Y*, Ohba S*, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI: Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8(4): e60203, 2013
  23. Hojo H*, Ohba S*, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI: Gli1 protein participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification. J Biol Chem 287(21):17860-17869, 2012
  24. Yamamoto K, Hojo H, Koshima I, Chung UI, Ohba S*: Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res 30(12):1958-1962, 2012
  25. Ohba S*, Hojo H, Chung UI: Bioactive factors for tissue regeneration: State of Art. Muscles Ligaments Tendons J 2(3):193-203, 2012
  26. Ohba S, Hojo H, Chung UI*: Current progress on tissue engineering of bone and cartilage. Endocrinol Metab 27(1):1-11, 2012
  27. Ohba S, Yano F, Chung UI*: Tissue engineering of bone and cartilage. IBMS BoneKEy 6(11):405-419, 2009
  28. Ohba S*, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI*: Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 14(5):689-699, 2008
  29. Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI*: A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun 357(4):854-860, 2007
  30. Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H*: PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113(6):846-855, 2004
  31. Long F†, Chung UI†, Ohba S, McMahon J, Kronenberg HM, McMahon AP*: Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131(6):1309-1318, 2004 (†equal contribution)


[宮崎・森石]

  1. Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, Miyazaki T, Liu W, Fukuyama R, Wang Y, Komori H, Qin X, Amizuka N, Komori T*: Osteocalcin Is Necessary for the Alignment of Apatite Crystallites, but Not Glucose Metabolism, Testosterone Synthesis, or Muscle Mass. PLOS Genet 16(5):e1008586, 2020
  2. Miyazaki T, T Baba T, Mori M, Komori T*: Collapsin Response Mediator Protein 1, a Novel Marker Protein for Differentiated Odontoblasts. Acta Histochem Cytochem 51(6):185-190, 2018
  3. Miyazaki T, Baba TT, Mori M, Moriishi T, Komori T*: Microtubule-associated protein tau (Mapt) is expressed in terminally differentiated odontoblasts and severely down-regulated in morphologically disturbed odontoblasts of Runx2 transgenic mice. Cell Tissue Res 361(2):457-466, 2015
  4. Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T*: Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength. J Bone Miner Res 31(7):1366-80, 2016
  5. Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T*: Bcl2 Deficiency Activates FoxO through Akt Inactivation and Accelerates Osteoblast Differentiation. PLoS ONE 9(1):e86629, 2014
  6. Miyazaki T, Mori M, Yoshida CA, Ito C, Yamatoya K, Moriishi T, Kawai Y, Komori H, Kawane T, Izumi S, Toshimori K, Komori T*: Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia.
    Histochem Cell Biol 139(2):339-354, 2013
  7. Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T*: Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PLoS ONE 7(6):e40143, 2012
  8. Miyazaki T, Kanatani N, Rokutanda S, Yoshida C, Toyosawa S, Nakamura R, Takada S, Komori T*: Inhibition of the terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice. Arch Histol Cytol 71(2):131-146, 2008

和文総説・解説

  1. 大庭伸介, 北條宏徳:ゲノムワイドデータとバイオインフォマティクスに基づく転写制御因子とゲノムDNAの相互作用分析(特集:バイオマテリアル研究に役立つ分析技術・評価法), バイオマテリアル-生体材料- 37(4):244-251, 2019
  2. 大庭伸介:骨軟骨発生の制御メカニズムを基盤にした組織再生療法, Clin Calcium 26(12):1765-1771, 2016
  3. 菅家康介, 鄭雄一, 大庭伸介:人工骨による骨再生, 腎と骨代謝 28(4):285-292, 2015
  4. 菅家康介, 鄭雄一, 大庭伸介:ヘッジホッグシグナルによる軟骨内骨化の制御, THE BONE 27(4):27-33, 2013
  5. 菅家康介, 大庭伸介, 鄭雄一:骨・軟骨形成の分子基盤と再生医療, 細胞 45(1):5-8, 2013
  6. 北條宏徳, 大庭伸介, 鄭雄一:目で見るBone Biology「ヘッジホッグ(Hh)シグナル」, 骨粗鬆症治療 12(3):1-4, 2013
  7. 大庭伸介, 鄭雄一:骨形成シグナルの解明と人工骨の開発, Clin Calcium 23(12):31-37, 2013
  8. 大庭伸介:骨・軟骨形成性低分子化合物の同定と組織再建への応用. Nano Bio f 3:10-11, 2012
  9. 大庭伸介, 鄭雄一:再生医療とDDS, Drug delivery system 26(1), 46-51, 2011
  10. 北條宏徳, 大庭伸介, 鄭雄一:軟骨内骨化におけるヘッジホッグシグナルの役割, 細胞工学 30(3), 238-242, 2011
  11. 北條宏徳, 大庭伸介, 鄭雄一:肥大軟骨細胞は軟骨内骨化における軟骨形成と骨形成を制御する, 口腔組織培養学会誌 19(2):1-11, 2010
  12. 小笠原徹, 大庭伸介:細胞周期制御を利用した骨粗鬆症治療法開発のための基礎的研究, Osteoporosis Japan 18(4):61-63, 2010
  13. 大庭伸介, 鄭雄一:骨軟骨領域における再生医学の現状と展望, BIO Clinica 25(1):32-35, 2010
  14. 緒方直史, 大庭伸介, 鄭雄一, 川口浩:骨代謝と骨形成~骨形成への最適化シグナル~, Clin Calcium 18(12):1707-1712, 2008
  15. 大庭伸介, 鄭雄一:Cbfbの制御を介したBMPシグナルとRunx2による骨芽細胞分化, 新時代の骨粗鬆症学 増刊号:71-74, 2007
  16. 大庭伸介, 井川和代, 中村耕三, 川口浩, 高戸毅, 鄭雄一:骨・軟骨の再生医療, 日本老年医学会雑誌 41(6):582-588, 2004
  17. 大庭伸介, 鄭雄一:ヘッジホッグと軟骨細胞, 腎と骨代謝16(3):229-236, 2003
  18. 大庭伸介, 鄭雄一:PTHrPの作用, 腎と骨代謝 16(2):131-141, 2003

著 書

  1. 北條宏徳, 鄭雄一, 大庭伸介:第2章14-骨再生医療等の現状と課題, 先進医療NAVIGATOR 再生医療・細胞医療の研究と産業化の最前線(先進医療フォーラム編), 73-75, 日本医学出版, 東京, 2018
  2. 大庭伸介:15章3節 骨形成と転写制御, 遺伝子発現制御機構 クロマチン・転写制御・エピジェネティクス(田村隆明, 浦聖恵編), 164-166, 東京化学同人, 東京, 2017
  3. 大庭伸介:コラム-変形性関節症の遺伝子治療, 最新医学別冊 診断と治療のABC「変形性関節症」, 147-148, 最新医学社, 東京, 2017
  4. 大庭伸介, 鄭雄一:第11章Hedgehogシグナル, サイトカイン・増殖因子キーワード事典(宮園浩平, 秋山徹, 宮島篤, 宮沢恵二編)375-383, 羊土社, 東京, 2015
  5. 大庭伸介, 鄭雄一:多能性幹細胞を使った骨再生, 再生医療叢書(日本再生医療学会監修)-6 骨格系(脇谷滋之, 鄭雄一編), 128-140, 朝倉書店, 東京, 2012
  6. 大庭伸介:骨形成シグナルの解明と骨再生医学への応用, 医薬理工の異分野融合研究から見えたナノバイオの未来(東京大学ナノバイオインテグレーション研究拠点編), 60, エクスナレッジ, 東京, 2010
  7. 大庭伸介, 鄭雄一:骨代謝を制御する因子, 最新整形外科学体系(越智隆弘編)1 運動器の生物学と生体力学, 19-24, 中山書店, 東京, 2008
  8. 大庭伸介, 鄭雄一:組織再生誘導と分子シグナルの最適化, ティッシュエンジニアリング2007(田畑泰彦, 岡野光夫監修), 96-99, 日本医学館, 東京, 2007
  9. 大庭伸介, 井川和代, 中村耕三, 川口浩, 高戸毅, 鄭雄一:骨・軟骨の再生医療, 老年医学update 2005-06(日本老年医学会雑誌編集委員会編), 199-206, メジカルビュー社, 東京, 2005

その他解説等

  1. 大庭伸介:海外文献紹介-軟骨再生と関節損傷の修復のための内在性線維軟骨幹細胞の利用. The Bone 30(4):413, 2016
  2. 大庭伸介:海外文献紹介-ラットにおいて, インプラント由来マグネシウムは局所ニューロンのCGRP産生を誘導し, 骨折治癒を改善する. The Bone 30(4):413, 2016
長崎大学
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