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HOME＞研究報告＞2008年度「口腔環境制御研究」報告：広島大学歯学部

２００８年度「口腔環境制御研究」報告： 広島大学歯学部
 
１．「口腔環境制御研究」に関する論文リスト
  1. Nikawa H, Igarashi S, Takasu O, Tanaka H, Harano F, Shinohara S, Makihira S, Takemoto T, Murayama T, Satoda T, Amano H, Kurihara H. Chewing Gum Containing Citric Acid Reduces the Burden of Periodontal pathogens. Open Food Sci J, 2, 29-37, 2008.
  2. Sugiura Y, Soga Y, Tanimoto I, Kokeguchi S, Nishide S, Kono K, Takahashi K, Fujii N, Ishimaru F, Tanimoto M, Yamabe K, Tsutani S, Nishimura F, Takashiba S. Antimicrobial effects of the saliva substitute, Oralbalanceｨ, against microorganisms from oral mucosa in the hematopoietic cell transplantation period. Supportive Care Cancer 16:421-424, 2008.
  3. Takeuchi-Hatanaka K, Ohyama H, Nishimura F, Kato-Kogoe N, Soga Y, Matsushita S, Nakasho K, Yamanegi K, Yamada N, Terada N, Shogo Takashiba. Polymorphisms in the 5ﾕ flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population. J Clin Periodontol 35:317-323, 2008.
  4. Ohyama H, Kato-Kogoe N, Nishimura F, Takeuchi-Hatanaka K, Matsushita S, Yamanegi K, Yamada N, Hata M, Nakasho K, Terada N. Differential effects of polymorphisms in the 5ﾕ flanking region of IL12RB2 on NK and T cell activity. J Interferon Cytokine Res, 28:563-569, 2008.
  5. Sugiura Y, Soga Y, Nishide S, Kono K, Takahashi K, Fujii N, Ishimaru F, Tanimoto M, Nishimura F, Takashiba S. Evaluation of xerostomia in hematopoietic cell transplantation by a simple capacitance. Supportive Care Cancer, 16:1197-1200, 2008.
  6. Yamaguchi T, Naruishi K, Arai H, Nishimura F, Takashiba S. IL-6/sIL-6 enhance cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts. J Cell Physiol, 217:423-432, 2008.
  7. Miyagawa J, Maeda H, Murauchi T, Kokeguchi S, Yamabe K, Tanimoto I, Nishimura F, Fukui K, Takashiba S. Rapid and simple detection of eight major periodontal pathogens by the loop-mediated isothermal amplification method. FEMS Immunol Med Microbiol. 53:314-321, 2008.
  8. Yamashita A, Soga Y, Iwamoto Y, Asano T, Li Y, Abiko Y, Nishimura F. DNA microarray analyses of genes expressed differentially in 3T3-L1 adipocytes co-cultured with murine macrophage cell line RAW 264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin. Int J Obese, 32: 1725-1729, 2008.
  9. Soga Y, Yamasuji Y, Kudo C, Matsuura-Yoshimoto K, Yamabe K, Sugiura Y, Maeda Y, Ishimaru F, Tanimoto M, Nishimura F, Takashiba S. Febrile neutropenia and periodontitis: lessons from a case periodontal treatment in the intervals between chemotherapy cycles for leukemia reduced febrile neutropenia. Support Care Cancer, [Epub ahead of print], 2008.
  10. Okada Y, Meguro M, Ohyama H, Yoshizawa S, Takeuchi-Hatanaka K, Kato N, Matsushita S, Takashiba S, Nishimura F. HLA-II - induced cytokines from human gingival fibroblasts promotes proliferation of human umbilical vein endothelial (HUVEC) cells: potential association with enhanced angiogenesis in chronic periodontal inflammation. J Periodontal Res, 44:103-109, 2009.
  11. Nishifuji K, Sugai M, Amagai M. Staphylococcal exfoliative toxins: "molecular scissors" of bacteria that attack the cutaneous defense barrier in mammals.　J Dermatol Sci 2008 Jan;49(1):21-31.
  12. Ohara M, Hayashi T, Kusunoki Y, Nakachi K, Fujiwara T, Komatsuzawa H, Sugai M.
    Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells.　Infect Immun 2008 Oct;76(10):4783-91.
  13. Ouhara K, Komatsuzawa H, Kawai T, Nishi H, Fujiwara T, Fujiue Y, Kuwabara M, Sayama K, Hashimoto K, Sugai M.　Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus.　J Antimicrob Chemother 2008 Jun;61(6):1266-9.
  14. Toth I, Nougayrede JP, Dobrindt U, Ledger TN, Boury M, Morabito S, Fujiwara T, Sugai M, Hacker J, Oswald E.　Cytolethal distending toxin type I and type IV genes are framed with lambdoid prophage genes in extraintestinal pathogenic Escherichia coli.　Infect Immun 2009 Jan;77(1):492-500.
  15. Tsuruda K, Shimazu A, Sugai M.　Detection of a single bacterial cell using a 16S ribosomal RNA-specific oligonucleotide probe designed to investigate periodontal pathogens.　Oral Microbiol Immunol 2009 Apr;24(2):133-40.
  16. Ling Zhu, Koichi Inoue, Satoshi Yoshizumi, Hiroshi Kobayashi, Ming Ouyang, Fuminori Kato, Motoyuki Sugai, Masayori Inoue　Staphylococcus aureus MazF specifically cleaves pentad sequence UACAU, which is unusually highly abundant in the pathogenic adhesive factor Srap.　Journal of Bacteriology in press

２．特許の出願状況（出願特許名等）
  1. 特願2008-123450号　「洗浄方法および被洗浄物品」
    出願人　広島大学
    発明者：二川　浩樹
    出願日 : ２００８年５月９日
  2. 特願2008-256236号　「物品表面の藻類発生抑制剤及び藻類発生抑制処理方法」
    出願人　広島大学，中国鉄管継手株式会社　高田祐司
    発明者：二川　浩樹　中国鉄管継手株式会社　高田祐司
    出願日 : ２００８年１０月１日
    出願番号2004298951　(オーストラリア)
  3. 特許登録　AU 2004298951 B2　ストレプトコッカス・ミュータンス及びストレプトコッカスソブリヌスに対する殺菌剤
    出願人　ツーセル
    発明者　菅井　基行・小松澤均
    登録日　2008.1.4


３．記載すべき重要な発見・発明
  1. 内臓肥満に感染による負荷が加わることでインスリン抵抗性、動脈硬化の進行を促進する遺伝子の発現が著明に上昇し、一方で細胞のエネルギー代謝に関係する遺伝子の発現は低下することを発見した。すなわち、感染の制御が内臓肥満に関連する疾病の治療の標的の一つとなる可能性を示した（Yamashita A, Soga Y, Iwamoto Y, Asano T, Li Y, Abiko Y, Nishimura F. DNA microarray analyses of genes expressed differentially in 3T3-L1 adipocytes co-cultured with murine macrophage cell line RAW 264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin. Int J Obese, 32: 1725-1729, 2008.）

４．受賞
  1. 山下明子
    2008年度日本歯周病学会奨励賞（受賞論文：　Yamashita A, Soga Y, Iwamoto Y, Yoshizawa S, Iwata H, Kokeguchi S, Takashiba S, Nishimura F. Macrophage-adipocyte interaction: Marked IL-6 production by co-cultures stimulated with LPS. Obesity, 15:2549-2552, 2007.）
  2. 清水　亘
    2008年度日本化学療法学会西日本支部長賞−臨床部門
    「2007年度広島地区における院内分離耐性緑膿菌に関する検討−多剤耐性緑膿菌を中心に−」　清水亘、小林加直、甲田俊太郎、大毛宏喜、菅井基行

 
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