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HOME＞研究報告＞2010年度「口腔環境制御研究」報告：広島大学歯学部

２０１０年度「口腔環境制御研究」報告： 広島大学歯学部
 
【原著】
  1. Mine Y, Makihira S, Nikawa H, Murata H, Hosokawa R, Hiyama A, Mimura S. : Impact of titanium ions on osteoblast-, osteoclast- and gingival epithelial-like cells. Journal of Prosthodontic Research. 54:1-6. 2010
  2. Makihira S, Mine Y, Nikawa H, Shuto T, Kosaka E, Sugiyama M, Hosokawa R. : Immobilized-OPG-Fc on a titanium surface inhibits RANKL-dependent osteoclast differentiation in vitro. Journal of Materials Science: Materials in Medicine. 21:647-53. 2010
  3. Shimoe S, Tanoue N, Satoda T, Murayama T, Nikawa H, Matsumura H. :Evaluation of single liquid primers with organic sulfur compound for bonding between indirect composite material and silver-palladium-copper-gold alloy. Dental Materials Journal. 29:25-9. 2010
  4. Makihira S, Shuto T, Nikawa H, Okamoto K, Mine Y, Takamoto Y, Ohara M, Tsuji K. : Titanium immobilized with an antimicrobial peptide derived from histatin accelerates the differentiation of osteoblastic cell line, MC3T3-E1. International Journal of Molecular Sciences. 11:1458-70. 2010
  5. Murata H, Chimori H, Hong G, Hamada T, Nikawa H. : Compatibility of tissue conditioners and denture cleansers: influence on surface conditions. Dental Materials Journal. 29:446-53. 2010
  6. Makihira S, Mine Y, Nikawa H, Shuto T, Iwata S, Hosokawa R, Kamoi K, Okazaki S, Yamaguchi Y. : Titanium ion induces necrosis and sensitivity to lipopolysaccharide in gingival epithelial-like cells.  Toxicology in Vitro. 24:1905-10. 2010
  7. Mori H, Horiuchi S, Nishimura S, Nikawa H, Murayama T, Ueda K, Ogawa D, Kuroda S, Kawano F, Naito H, Tanaka M, Koolstra JH, Tanaka E. : Three-dimensional finite element analysis of cartilaginous tissues in human temporomandibular joint during prolonged clenching.  Archives of Oral Biology. 55:879-86.2010
  8. Mimura S., Kimura N., Hirata M., Tateyama D., Hayashida M., Umezawa A., Kohara A., Nikawa H., Okamoto T., Furue M. K.. : Growth factor-defined culture medium for human mesenchymal stem cells. International Journal of Developmental Biology (in press)
  9. 木原琢也，下江宰司，二川浩樹，村山 長，牧平清超，里田隆博，玉本光弘，河原和子，笹原妃佐子，熊谷 宏：非接触式三次元形状計測装置を用いた歯型彫刻製作物の客観的評価の試み－体積と特徴点のずれの定量化－．日本歯科医学教育学会雑誌 26: 248-252．2010
  10. 檜山あや，二川浩樹，牧平清超，三村純代，高本祐子，峯 裕一，野宗万喜：口腔由来乳酸菌株によるmutans streptococciに対する抗菌性に関する研究：機能食品と薬理栄養 6:157-62. 2010
  11. 檜山あや，高本祐子，二川浩樹，牧平清超，三村純代，大前侑子，柚下香織，平松美菜子，田村智哉：むし歯菌・歯周病菌を抑制する乳酸菌を用いたヨーグルトの開発 食品工業別冊，（Vol.53 No.6），62-68，2010
  12. Kato-Kogoe N, Ohyama H, Nishimura F, Meguro M, Yoshizawa S, Okada Y, Nakasyo K, Yamanegi K, Yamada N, Hata M, Higashi T, Terada N, Matsushita S. Fibroblasts stimulated via HLA-II molecules produce PGE2 and regulate cytokine production from Th cells. Lab Invest, in press, 2010.
  13. Soga Y, Maeda Y, Ishimaru F, Tanimoto M, Maeda H, Nishimura F, Takashiba S. Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation. Supoortive Care in Cancer, in press, 2010.
  14. Yoneda M, Guo Y, Ono H, Nakatsu Y, Zhang J, Cui XL, Iwashita M, Kumamoto S, Tsuchiya Y, Sakoda H, Fujishiro M, Kushiyama A, Koketsu Y, Kikuchi T, Kamata H, Nishimura F, Asano T. Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase. Obese Res Clin Pract, 4:e201-e207, 2010.
  15. Nakarai H, Yamashita A, Takagi M, Adachi M, Sugiyama M, Noda H, Katano M, Yamakawa R, Nakayama K, Takumiya H, Nakai Y, Taniguchi A, Nishimura F. Periodontal disease and hyper-triglyceridemia in Japanese subjects : potential association with enhanced lipolysis. Metabolism, in press, 2010.
  16. Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T. Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity. J Biol Chem, in press, 2010.
  17. Ohyama H, Hongyo H, Shimizu N, Shimizu Y, Nishimura F, Nakagawa M, Arai H, Kato-Kogoe N, Terada N, Nagai A, Takashiba S, Kurihara H, Nomura Y, Murayama Y. Clinical and immunological assessment of periodontal disease in Japanese leprosy patients. Jpn J Infect Dis, 63: 427-432, 2010.
  18. Nakarai H, Yamashita A, Nagayasu S, Iwashita M, Kumamoto S, Ohyama H, Hata M, Soga Y, Kushiyama A, Asano T, Abiko Y, Nishimura F. Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications. Innate Immunity, in press, 2010.
  19. Bolduc V, Marlow G, Boycott KM, Saleki K, Inoue H, Kroon J, Itakura M,
    Robitaille Y, Parent L, Baas F, Mizuta K, Kamata N, Richard I, Linssen
    WH, Mahjneh I, de Visser M, Bashir R, Brais B. Recessive mutations in the putative calcium-activated Chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies. Am J Hum Genet. 86 (2):213-21, 2010
  20. Ohta K, Takechi M, Minami M, Shigeishi H,HiraokaM,　Nishimura M,　Kamata N.Influence of factors related to implant stability detected by
    wireless resonance frequency analysis device. Journal of Oral Rehabilitation .37(2): 131-7, 2010
  21. Ohta K, Ogawa I, Ono S, Taki M, Mizuta K, Miyauchi M, Takechi M, Shigeishi H, Takata T, Kamata N. Histopathological evaluation including Cytokeratin13 and Ki-67 in the border　between Lugol-stained and unstained areas. Oncology reports 24(1): 9-14, 2010
  22. Ohta K, NishiH,　Fukui A, Shigeishi H, Takechi M, Kamata N. CX3CL1 expression induced by Candida albicans in oral fibroblasts.　FEMS Immunol Med Microbiol.;60(2):179-85、2010
  23. NishiH, Ohta K, Takechi M, Yoneda S, Hiraoka M, Kamata N. Wound healing effects of gingival fibroblasts cultured in animal-free medium． Oral
    Disease 16(5):438-44, 2010
  24. Mitani Y, Li J, Rao HP, Zhao Y, Bell D, Lippman MS, Weber SR, Caulin C, EI-Naggar, K Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: incidence, variability and clinicopathological significance. Clinical Cancer Research 16(19):4722-31, 2010
  25. 水田邦子，小野重弘， 藤本伸一，奥井　岳，三谷佳嗣，武知正晃，鎌田伸之: FDG PET-CT検査により同時性重複癌を検出した舌癌の2例. 広島大学歯学雑誌 第42巻2号185-190,2010
  26. Gefron C. Franke, Alexandra Bockenholt, Motoyuki Sugai, Holger Rohde, and Martin Aepfelbacher. Epidemiology, variable genetic organization and regulation of the EDIN-B toxin in Staphylococcus aureus from bacteremic patients. Microbiology 156:860-872, 2010
  27. Oranart Matangkasombut, Roongtiwa Wattanawaraporn, Keiko Tsuruda, Masaru Ohara, Motoyuki Sugai, Skorn Mongkolsuk. Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest and caspase-independent death in budding yeast model. Infection and Immunity 78:783-792, 2010
  28. Okada M, Taniguchi Y, Hayashi F, Doi T, Suzuki J, Sugai M and Kozai K. Late established mutans stpeptococci in children over 3 years old. International Journal of Dentistry 732468 Epub 2010
  29. Miki Matsuo, Fuminori Kato, Yuichi Oogai, Toshihisa Kawai, Motoyuki Sugai, Hitoshi Komatsuzawa. Distinct two-component systems in methicillin-resistant Staphylococcus aureus can change the susceptibility to antimicrobial agents. Journal of Antimicrobial Chemotherapy 65:1536-1537, 2010
  30. Keita Iyori, Junzo Hisatsune, Tetsuji Kawakami, Sanae Shibata, Nobuo Murayama, Kaori Ide, Masahiko Nagata, Tsuneo Fukata, Toshiroh Iwasaki, Kenshiro Oshima, Masahira Hattori, Motoyuki Sugai, Koji Nishifuji. Identification of a novel Staphylococcus pseudintermedius exfoliative toxin gene and its prevalence in isolates from canines with pyoderma and healthy dogs. FEMS Microbiology Letters 312:169-175, 2010
  31. Florian H. Pilsczek, Davide Salina, Karen K. H. Poon, Candace Fahey, Bryan G. Yipp, Christopher D. Sibley, Stephen M. Robbins, Francis H. Y. Green, Mike G. Surette, Motoyuki Sugai, M. Gabriela Bowden, Muzaffar Hussain, Kunyan Zhang, Paul Kubes A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus Journal of Immunology 185, 7413-7425, 2010.
  32. Yoshijima Y, Murakami K, Kayama S, Liu D, Hirota K, Ichikawa T, Miyake Y. Effect of substrate surface hydrophobicity on the adherence of yeast and hyphal Candida. Mycoses. 2010 53(3):221-6, 2010.
  33. Hirota K, Yoneyama T, Sakamoto M, Miyamoto H, Kurihara M, Kayama S, Murakami K, Yumoto H, Matsuo T, Miyake Y. High prevalence of Pseudomonas aeruginosa from oropharyngeal biofilm in patients with cerebrovascular infarction and dysphagia. Chest. 2010 138(1):237-8, 2010.


【総説】
  1. 二川浩樹，柚下香織，平松美菜子，坂口剛正：インフルエンザの拡大リスクを軽減する化合物 ケミカルエンジニアリングVol55. No.8 .41-47, 2010
  2. 西村英紀. 歯周病と肥満. 日本咀嚼学会雑誌, 20: 56-60, 2010.


【特許関連】
  1. 特願2007-193786 「固形化した洗浄剤組成物およびその製造方法」出願人　広島大学　発明者：二川　浩樹　出願日 : ２００７年７月２５日（PCT出願　アメリカ，イギリス）
    PCT出願（PCT/JP2008/062164）US,EP,KR,CN,AU,JPへ移行
  2. 特願2008-123450号　「洗浄方法および被洗浄物品」出願人　広島大学　発明者：二川　浩樹　出願日 : ２００８年５月９日　2010年US,EP,KR,CN,AU,JP,MYへの移行
  3. 特願2008-329036号「洗浄剤組成物、消毒・洗浄・洗口・除菌及び抗菌化用組成物、消毒・洗浄・除菌及び抗菌化方法、洗口方法、抗菌物質の安定化方法、歯の抗菌化方法並びにウイルス不活性化方法」　出願人　広島大学，マナック株式会社　発明者：二川　浩樹，竹田　宏紀、柿原　俊夫　出願日 : ２００８年１２月２５日　PCT出願（PCT/JP2009/068929）JP移行済み　→2010－543968，2011-008174の２つに分割出願
  4. 商標第5313599号　（2010年4月2日）フルプロテクション　第5類衛生消毒剤，消毒液，消毒薬，スプレー式殺菌消毒薬，医療用油紙，衛生マスク，など　第25類　制服，作業服，その他の被服（商願2009-082727　2009年10月31日）株式会社Campus Medico
  5. 商標登録5326583（2010年5月28日）Etak　第1類化学剤　第3類　洗剤　（商願2009-081638　2009年10月28日）　広島大学。
  6. 商標登録5331825（2010年6月18日）L8020　第5類食品強化剤　第29類　乳飲料　（商願2009-088424　2009年11月20日）　広島大学。
  7. 特願2011-027882　「塩基性抗菌ペプチドおよびその利用方法」出願人　国立大学法人広島大学　出願日　平成２３年２月１０日
  8. 商標登録5394691（2011年3月4日）Etak　第1類化学剤　第3類　洗剤　（商願2010-055149　2010年7月13日）　広島大学。
  9. Bactericide against streptococcus mutans and streptococcus sobrinus. European Patent Application No. 04820505.8  July 28, 2010
  10. Bactericide against streptococcus mutans and streptococcus sobrinus. US Letters Patent No. 7,776,325 Sept 1, 2010


【実施許諾と製品】
  1. Etak in フルプロテクション０　　　（ジェクス株式会社）H21.12～
  2. クレンゼ　抗ウィルス布・白衣など　（倉敷紡績（株））  H22.4~
  3. 抗ウィルス学校体育用ウエア　　　　（アシックス（株））H22.4～
  4. 抗ウィルスタオル　　　　　　　　　（（株）樟橋紋織）H22.4～
  5. 8020ヨーグルト　　　　　　　　　　（四国乳業（株））H22.10～

 
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