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ホーム教育研究活動研究分野(旧講座)>細胞生物学(旧口腔解剖学第二)

細胞生物学(旧口腔解剖学第二) 概要

長崎大学大学院医歯薬学総合研究科医療科学専攻
細胞生物学分野
Tel: 095-819-7631(受付)
Fax: 095-819-7633
ホームページ分野独自のホームページ
Department of Cell Biology,
Medical and Dental Sciences,
Graduate School of Biomedical Sciences,
Nagasaki University

指導教員
職名 氏名 E-mail 学位
教 授  小守 壽文
医学博士
准教授  宮崎 敏博
歯学博士
助 教  森石 武史
歯学博士

教育活動 
 (学部教育)
 発生学 2年次・後期
 組織学及び同実習 2年次・前期
 口腔組織学及び同実習 3年次・後期
 歯学展望 1年次・前期
 細胞生物学プラクシス 1年次・前期
 基礎歯学研究概論 3年次・前期
 基礎歯学研究 3,4年次・通年
 硬組織科学 5年次・前期
 歯学研究 5,6年次・通年
 基礎歯学輪講 6年次・前期
 (大学院教育)
 細胞生物学演習 1,2年次・通年
 細胞生物学実習 1,2年次・通年
 細胞生物学論文研究 1,2年次・通年
 硬組織科学 1,2年次・後期
 (全学教育)
 口腔健康管理と審美U・食の科学 2年次・第3Q

主な研究テーマ
  • 間葉系幹細胞の分化決定機構
  • 骨芽細胞の分化・増殖の分子機構
  • 軟骨細胞の分化・増殖の分子機構
  • 骨格形成の分子機構
  • 歯の発生の分子機構
  • 骨の形成と維持機構
  • 骨・軟骨再生
  • Runx2の転写制御機構の解明

主な原著論文
  1. Yang M, Arai A, Udagawa N, Hiraga T, Lijuan Z, Ito S, Komori T, Moriishi T, Matsuo K, Shimoda K, Zahalka AH, Kobayashi Y, Takahashi N, Mizoguchi T: Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy. Sci Rep. 2017 Jul 10;7(1):4928. doi: 10.1038/s***************-1.
  2. Miyazaki T, Inoue M, Baba T, Komori T: Overexpression of Sp7 in odontoblasts results in dentinogenesis imperfecta due to the inhibition of odontoblast maturation. J Oral Biosci. 59(2)113-120, 2017 May.
  3. Oya K, Ishida K, Nishida T, Sato S, Kishino M, Hirose K, Ogawa Y, Ikebe K, Takeshige F, Yasuda H, Komori T, Toyosawa S: Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization. Histochem Cell Biol. 2017 Mar; 147(3):341-351.
  4. Komori T: Roles of Runx2 in skeletal development. Adv Exp Med Biol. 962:83-93, 2017 Mar.
  5. Komori T: Cell Death in Chondrocytes, Osteoblasts, and Osteocytes. Int J Mol Sci. 2016 Nov, 17(12): E2045
  6. Komori T: Glucocorticoid signaling and bone biology. Horm Metab Res. 48(11):755-763, 2016 Nov.
  7. Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T: Overexpression of BCLXL in osteoblasts inhibits osteoblast apoptosis and increases bone volume and strength. J Bone Miner Res. 31(7):1366-80, 2016 jul.
  8. Jiang Q, Qin X, Kawane T, Matsuo Y, Taniuchi I, Komori H, Ito K, Izumi S, Komori T: Cbfb2 isoform dominates more potent Cbfb1 and is required for skeletal development. J Bone Miner Res. 31(7):1391-404, 2016 jul.
  9. Miyazaki T, Baba T, Mori M, Moriishi T, Komori T: Microtubule-associated protein tau (Mapt) is expressed in terminally differentiated odontoblasts and severely down-regulated in morphologically disturbed odontoblasts of Runx2 transgenic mice. Cell Tissue Res. 361(2):457-66, 2015 Aug.
  10. Komori T: Animal models for osteoporosis. Eur J Pharmacol. 759:287-94, 2015 jul.
  11. Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T: Cbfb regulates bone development by stabilizing Runx family proteins. J Bone Miner Res. 30(4):706-14, 2015 Apr.
  12. Nakamura T, Naruse M, Chiba Y, Komori T, Sasaki K, Iwamoto M, Fukumoto S: Novel hedgehog agonists promote osteoblast differentiation in mesenchymal stem cells. J Cell Physiol. 230(4):922-9, 2015 Apr.
  13. Komori T: The functions of Runx family transcription factors and Cbfb in skeletal development. Oral sci.int. 12(1):1-4, 2015 Jan.
  14. Yoshida CA, Kawane T, Moriishi T, Purushothaman A, Miyazaki T, Komori H, Mori M, Qin X, Hashimoto A, Sugahara K, Yamana K, Takada K, Komori T: Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin type O-glycans and reduction of glycosaminoglycans. J Biol Chem. 289(38):26584-96, 2014.
  15. Komori T: A review of the differing roles of dead and live osteocytes. Journal of Oral Biosciences. 56(3):101-104, 2014.
  16. Kawane T, Komori H, Liu W, Moriishi T, Miyazaki T, Mori M, Matsuo Y, Takada Y, Izumi S, Jiang Q, Nishimura R, Kawai Y, Komori T: Dlx5 and Mef2 Regulate a novel Runx2 enhancer for osteoblast-specific expression. J Bone Miner Res. 29(9):1960-1969, 2014.
  17. Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T: Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation. PLoS One. 9(1):e86629. 2014.
  18. Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T: Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum Mol Genet. 23(11):2953-67, 2014.
  19. Ito K, Maruyama Z, Sakai A, Izumi S, Moriishi T, Yoshida CA, Miyazaki T, Komori H, Takada K, Kawaguchi H, Komori T: Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53dependent apoptosis without enhancing proliferation. Oncogene. 33(14):1862-71, 2014.
  20. Yoon WJ, Islam R, Cho YD, Woo KM, Baek JH, Uchida T, Komori T, van Wijnen A, Stein JL, Lian JB, Stein GS, Choi JY, Bae SC, Ryoo HM: Pin1-mediated Runx2 modification is critical for skeletal development. J Cell Physiol. 228(12):2377-85, 2013.
  21. Komori T: Regulation of Rb family proteins by Cdk6/Ccnd1 in growth plates. Cell Cycle. 12(14):2161-2162, 2013.
  22. Komori T: Functions of the osteocyte network in the regulation of bone mass. Cell Tissue Res. 352(2):191-198, 2013.
  23. Watanabe T, Oyama T, Asada M, Harada D, Ito Y, Inagawa M, Suzuki Y, Sugano S, Katsube K, Karsenty G, Komori T, Kitagawa M, Asahara H: MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLos Genet. 9(1):e1003132. 2013.
  24. Miyazaki T, Mori M, Yoshida CA, Ito C, Yamatoya K, Moriishi T, Kawai Y, Komori H, Kawane T, Izumi S, Toshimori K, Komori T: Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia. Histochem Cell Biol. 139(2):339-354, 2013.
  25. Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M: In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues. Sci Rep. 2:642, 2012.
  26. Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T: Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PLoS One. 7(6):e40143. 2012.
  27. Masuyama R, Mizuno A, Komori H, Kajiya H, Uekawa A, Kitaura H, Okabe K, Ohyama K, Komori T: Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass. J Bone Miner Res. 27(8):1708-1721, 2012.
  28. Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, Moriishi T, Kawaguchi H, Takada K, Komori T: SP7 inhibits osteoblast differentiation at a late stage in mice. PLoS One. 7(3):e32364. 2012.
  29. Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T: Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis. Bone. 50(1):409-419, 2012.
  30. Moriishi T, Maruyama Z, Fukuyama R, Ito M, Miyazaki T, Kitaura H, Ohnishi H, Furuichi T, Kawai Y, Masuyama R, Komori H, Takada K, Kawaguchi H, Komori T: Overexpression of bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PLoS One. 6(11):e27487, 2011.
  31. Maeno T, Moriishi T, Yoshida CA, Komori H, Kanatani N, Izumi S, Takaoka K, Komori T. Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone. 49(4):673-682, 2011.
  32. Komori T: Signaling networks in RUNX2-dependent bone development. J Cell Biochem. 112(3):750-755, 2011.
  33. Mikasa M, Rokutanda S, Komori H, Ito K, Tsang YS, Date Y, Yoshida CA, Komori T: Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation. J Bone Miner Metab. 29(3):291-299, 2011.
  34. Watanabe K, Sugai M, Nambu Y, Osato M, Hayashi T, Kawaguchi M, Komori T, Ito Y, Shimizu A: Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF-{beta}1 and Retinoic Acid Signaling. J Immunol. 184(6):2785-2792, 2010.
  35. Komori T: Regulation of osteoblast differentiation by runx2. Adv Exp Med Biol. 658:43-49, 2010.
  36. Komori T: Regulation of osteoblast and odontoblast differentiation by Runx2. J Oral Biosci. 52(1):22-25, 2010.
  37. Komori T: Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res. 339(1):189-195, 2010.
  38. Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Komori H, Liu W, Mizuno A Komori T: Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol. 328(1):78-93, 2009.
  39. Kuo YH, Zaidi SK, Gornostaeva S, Komori T, Stein GS, Castilla LH: Runx2 induces acute myeloid leukemia in cooperation with Cbf{beta}-SMMHC in mice. Blood. 113(14):3323-3332, 2009.
  40. Miyazaki T, Kanatani N, Rokutanda S, Yoshida C, Toyosawa S, Nakamura R, Takada S, Komori T: Inhibition of terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice. Arch Histol Cytol. 71:131-146, 2008.
  41. Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, Iso T, Komori T, Arai M, Kurabayashi M: Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. Mol Cell Biol. 28(3):1147-60, 2008.
  42. Komori T: Regulation of bone development and maintenance by Runx2. Front Biosci. 13:898-903, 2008.
  43. Fukuoka H, Shibata S, Suda N, Yamashita Y, Komori T:Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice. J Anat. 211(1):8-15, 2007.
  44. Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura H, Nakamura K, Fujita T, Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, Komori T: Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn. 236(7):1876-1890, 2007.
  45. Iwamoto M, Tamamura Y, Koyama E, Komori T, Takeshita N, Williams JA, Nakamura T, Enomoto-Iwamoto M, Pacifici M. Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol. 305(1):40-51, 2007.
  46. Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M: Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J. 26(1):184-196, 2007.
  47. Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung UI, Kawaguchi H. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum. 54(8):2462-2470, 2006.
  48. Kanatani N, Fujita T, Fukuyama R, Liu W, Yoshida CA, Moriishi T, Yamana K, Miyazaki T, Toyosawa S, Komori T. Cbfb regulates Runx2 function isoform-dependently in postnatal bone development. Dev Biol. 296(1):48-61, 2006.
  49. Komori T: Regulation of osteoblast differentiation by transcription factors. J Cell Biochem. 99(5):1233-1239, 2006.
  50. Goto T, Matsui Y, Fernandes RJ, Hanson DA, Kubo T, Yukata K, Michigami T, Komori T, Fujita T, Yang L, Eyre DR, Yasui N: Sp1 family of transcription factors regulates the human a2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res. 21(5):661-673, 2006.
  51. Yoshida CA, Komori T: Role of Runx proteins in chondrogenesis. Crit Rev Eukaryot Gene Expr. 15(3):243-254, 2005.
  52. Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M: Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 280(19):19185-19195, 2005.
  53. Komori T: Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem. 95(3):445–453, 2005.
  54. Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H: Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 19(5):536-541, 2005.
  55. Fujita T, Fukuyama R, Enomoto H, Komori T: Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2. J Cell Biochem. 93(2):374-383, 2004.
  56. Toyosawa S, Kanatani N, Shintani S, Kobata M, Yuki M, Kishino M, Ijuhin N Komori T: Expression of dentin matrix protein 1 (DMP1) during fracture healing. Bone 35(2):553-561, 2004.
  57. Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida CA, Koida M, Ogita K, Komori T: Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol. 166(1):85-95, 2004.
  58. Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T: Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 18(8):952-963, 2004.
  59. Toyosawa S, Tomita Y, Kishino M, Hashimoto J, Ueda T, Tsujimura T, Aozasa K, Ijuhin N, Komori T: Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia. Mod Pathol. 17(5):573-578, 2004.
  60. Fukuyama R, Fujita T, Azuma Y, Hirano A, Nakamuta H, Koida M, Komori T: Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. Biochem Biophys Res Commun. 315(3):636-642, 2004.
  61. Enomoto H, Furuichi T, Zanma A, Yamana K, Yoshida C, Sumitani S, Yamamoto H, Enomoto-Iwamoto M, Iwamoto M, Komori T: Runx2 deficiency in chondrocytes causes adipogenic changes in vitro. J Cell Sci. 117(Pt3): 417-425, 2004.

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国立大学法人 長崎大学