Nishishita K, Sakai E, Okamoto K, Tsukuba T.: Structural and phylogenetic comparison of napsin genes: The duplication, loss of function and human-specific pseudogenization of napsin B. Gene 517(2):147-157, 2013
Sakai E, Shimada-Sugawara M, Yamaguchi Y, Sakamoto H, Fumimoto R, Fukuma Y, Nishishita K, Okamoto K, and Tsukuba T.: Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes. J. Pharmacol. Sci., 121(4):288-298, 2013
Yamaguchi Y, Sakai E, Sakamoto H, Fumimoto R, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T.： Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression. J Appl Toxicol. 2013 in press
2012
原著論文
Sakai E, Shimada-Sugawara M, Nishishita K, Fukuma Y, Naito M, Okamoto K, Nakayama K, Tsukuba T: Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis. J. Cell. Biochem. 113(2):486-98, 2012
Okamoto K, Okamoto Y, Kawakubo T, Iwata J, Yasuda Y, Tsukuba T, Yamamoto K: Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene. J. Biochem. 151(3):263-272, 2012
Narahara S, Matsushima H, Sakai E, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T: Genetic backgrounds and redox conditions influence morphological characteristics and cell differentiation of osteoclasts in mice. Cell. Tissue Res. 348(1): 81-94, 2012.
Fumimoto R, Sakai E, Yamaguchi Y, Sakamoto H, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T: The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation. J. Pharmacol. Sci., 118(4): 479-486, 2012
Sakamoto H, Sakai E, Fumimoto R, Yamaguchi Y, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T: Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenese-1 and NFATc1. Toxicol. in Vitro 26, 817-822, 2012
Sato T, Nishishita K, Okada Y, Toda K.: Efferent fibers innervate gustatory and mechanosensitive afferent fibers in frog fungiform papillae. Chem Senses. 37, 315-324. 2012
総説
Yamamoto K, Kawakubo T, Yasukochi A, Tsukuba T.: Emerging roles of cathepsin E in host defense mechanisms. Biochim Biophys Acta. 1824 (1), 105-112, 2012
Tsukuba T., Okamoto K., and Yamamoto K.: Cathepsin E is critical for proper trafficking of cell surface proteins J Oral Biosci. 54, 48-53, 2012.
2011
原著論文
Kawakubo T, Yasukochi A, Okamoto K, Okamoto Y, Nakamura S, Yamamoto K: The role of cathepsin E in terminal differentiation of keratinocytes. Biol. Chem. 392(6): 571-585, 2011
Yukitake H, Naito M, Sato K, Shoji M, Ohara N, Yoshimura M, Sakai E, Nakayama K: Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis. Microbiol Immunol. 55(3): 141-153, 2011
Ikeda H, Sumita Y, Ikeda M, Ikeda H, Okumura T, Sakai E, Nishimura M, Asahina I: Engineering bone formation from human dental pulp- and periodontal ligament-derived cells. Ann Biomed Eng. 39(1): 26-34, 2011
2010
原著論文
Sato T, Nishishita K, Okada Y, Toda K: The receptor potential of frog taste cells in response to cold and warm stimuli. Chem senses. 35(6): 491-499, 2010
2009
原著論文
Tsukuba T, Yanagawa M, Okamoto K, Okamoto Y, Yasuda Y, Nakayama K-I, Kadowaki T, Yamamoto K: Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages. J Biochem 145 (5): 565-573, 2009
Yasuda Y, Ohtomo E, Tsukuba T, Okamoto K, Saito T. Carbon dioxide laser irradiation stimulates mineralization in rat dental pulp cells. Int Endod J 42(10): 940-946 2009
Sato T, Nishishita K, Okada Y, Toda K: Interaction between gustatory depolarizing receptor potential and efferent-induced slow depolarizing synaptic potential in frog taste cell. Cell Mol Neurobiol 29(2): 243-52, 2009
Sato T, Nishishita K, Okada Y, Toda K: Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog. Cell Mol Neurobiol 29(4): 503-12, .2009
2008
原著論文
Hu J-P, Nishishita K, Sakai E, Yoshida H, Kato Y, Tsukuba T, Okamoto K: Berberine inhibits RANKL-induced osteoclast formation and survival through suppression of nuclear factor κB and Akt pathways. Eur J Pharmacol, 580 (1-2); 70-79, 2008
Shigematsu N, Fukuda T, Yamamoto T, Nishioku T, Yamaguchi T, Himeno M, Nakayama K-I, Tsukuba T, Kadowaki T, Okamoto K, Higuchi S, Yamamoto K: Association of cathepsin E deficiency with the increased territorial aggressive response of mice. J Neurochem 105 (4); 1394-1404, 2008
Ishida Y, Hu JP, Sakai E, Kadowaki T, Yamamoto Y, Tsukuba T, Kato Y, Nakayama K, Okamoto K: Determination of active site of Lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system. Arch Oral Biol, 53 (6); 538-544, 2008
Sato T, Nishishita K, Okada Y, Toda K: Electrical properties and gustatory responses of various taste disk cells frog fungiform papillae. Chem Senses 33 (4); 371-378, 2008
Yasuda Y, Izumikawa M, Okamoto K, Tsukuba T, Saito T: Dentin phosphophoryn promotes cellular migration of human dental pulp cells. J Endodont , 34 (5); 575-578, 2008
Kawakubo T, Yasukochi A, Tsukuba T, Kadowaki T, Yamamoto K: Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates. Biochimie 90(2); 396-404, 2008
2007
原著論文
Yanagawa M, Tsukuba T, Nishioku T, Okamoto Y, Okamoto K, Takii R, Terada Y, Nakayama K-I, Kadowaki T, Yamamoto K: Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages. J Biol Chem 282 (3): 1851-1862, 2007
Kakehashi H, Nishioku T, Tsukuba T, Kadowaki T, Nakamura S, Yamamoto K: Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E. J Immunol 179 (9): 5728-5737, 2007
Kawakubo T, Okamoto K, Iwata J, Shin M, Okamoto Y, Yasukochi A, Nakayama K-I, Kadowaki T, Tsukuba T, Yamamoto K: Cathepsin E Prevents Tumor Growth and Metastasis by Catalyzing the Proteolytic Release of Soluble TRAIL from Tumor Cell Surface. Cancer Res 67 (22): 10869-10878, 2007
Yamatake K, Maeda M, Kadowaki T, Takii R, Tsukuba T, Ueno T, Kominami E, Yokota S, Yamamoto K: Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells. Infect Immun 75 (5): 2090-2100, 2007
Sato T, Nishishita K, Mineda T, Okada Y, Toda K: Depression of gustatory receptor potential in frog taste cell by parasympathetic nerve-induced slow hyperpolarizing potential. Chem Senses 32 (1): 3-10, 2007
Sato T, Nishishita K, Okada Y, Toda K: Analysis of slow depolarizing potential in frog taste cell induced by parasympathetic efferent stimulation under hypoxia. Chem Senses 32 (4): 329-336, 2007
Hotokezaka H, Sakai E, Ohara N, Hotokezaka Y, Gonzales C, Matsuo K, Fujimura Y, Yoshida N, Nakayama K: Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycan. J Cell Biochem 101 (1): 122-34, 2007
Sakai E, Naito M, Sato K, Hotokezaka H, Kadowaki T, Kamaguchi A, Yamamot K, Okamoto K, Nakayama K: Construction of Recombinant Hemagglutinin Derived from the Gingipain-Encoding Gene of Porphyromonas gingivalis, Identification of its Target Protein on Erythrocytes, and Inhibition of Hemagglutination by an Interdomain Regional Peptide. J Bacteriol 189 (11): 3977-3986, 2007
Danjo A, Yamaza T, Kido MA, Shimohira D, Tsukuba T, Kagiya T, Yamashita Y, Nishijima K, Masuko S, Goto M, Tanaka T: Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation. Biochem Biophys Res Commun 360(1):199-204, 2007
Higashi Y, Nishishita K, Kato Y: Feeding Effects on Hypocalcemia Induced by Salicylic Acid Derivatives in the Rat. J Oral Biosci 49 (3): 190-197, 2007
Shin M, Kadowaki T, Iwata J, Kawakubo T, Yamaguchi N, Takii R, Tsukuba T, Yamamoto K: Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses. Biol Chem 388 (11): 1173-1181, 2007
Sato T, Nishishita K, Okada Y, Toda K: Characteristics of biphasic slow depolarizing and slow hyperpolarizing potential in frog taste cell induced by parasympathetic efferent stimulation. Chem Senses 32 (9): 817-823, 2007
総説
Kadowaki T, Takii R, Yamatake K, Kawakubo T, Tsukuba T, Yamamoto K: A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells. Front Biosci 12: 4800-4809, 2007
