研究業績 | 分子硬組織生物学（小守班）　骨・軟骨基盤創薬研究室

2022年

Komori T: Whole aspect of Runx2 functions in skeletal development. Int J Mol Sci. 23:5776, 2022.
doi: 10.3390/ijms23105776

Moriishi T, Komori T: Osteocytes: Their Lacunocanalicular Structure and Mechanoresponses. Int J Mol Sci. 2022, 23;4373. doi: 10.3390/ijms23084373.

Moriishi T, Ito T, Fukuyama R, Qin X, Komori H, Kaneko H, Matsuo Y, Yoshida N, Komori T：Sp7 Transgenic Mice with a Markedly Impaired Lacunocanalicular Network Induced Sost and Reduced Bone Mass by Unloading.
Int J Mol Sci. 2022 Mar 15;23(6):3173. doi: 10.3390/ijms23063173.

Otani S, Date Y, Ueno T, Ito T, Kajikawa S, Omori K, Taniuchi I, Umeda M, Komori T, Toguchida J, Ito K：Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Oncogene. 2022 Jan;41(5):683-691. doi: 10.1038/s41388-021-02120-w.

2021年

Nakamura E, Hata K, Takahata Y, Kurosaka H, Abe M, Abe T, Kihara M, Komori T, Kobayashi S, Murakami T, Inubushi T, Yamashiro T, Yamamoto S, Akiyama H, Kawaguchi M, Sakata N, Nishimura R: Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice. Commun Biol. 2021 Nov 3;4(1):1258. doi: 10.1038/s42003-021-02793-9.

Takahata Y, Hagino H, Kimura A, Urushizaki M, Kobayashi S, Wakamori K, Fujiwara C, Nakamura E, Yu K, Kiyonari H, Bando K, Murakami T, Komori T, Hata K, Nishimura R: Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.Commun Biol. 2021 Oct 19;4(1):1199. doi: 10.1038/s42003-021-02717-7.
PMID: 34667264

Mishima S, Takahashi K, Kiso H, Murashima-Suginami A, Tokita Y, Jo JI, Uozumi R, Nambu Y, Huang B, Harada H, Komori T, Sugai M, Tabata Y, Bessho K: Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice. Sci Rep. 2021 Jul 1;11(1):13674. doi: 10.1038/s41598-021-93256-y. PMID: 34211084

Qin X, Jiang Q, Komori H, Sakane C, Fukuyama R, Matsuo Y, Ito K, Miyazaki T, and Komori T: Runx2 is required for bone matrix protein gene expression in committed osteoblasts in mice. J Bone Miner Res. J Bone Miner Res. 2021 Oct;36(10):2081-2095. doi: 10.1002/jbmr.4386. Epub 2021 Jun 27.PMID: 34101902

Ono K, Hata K, Nakamura E, Ishihara S, Kobayashi S, Nakanishi M, Yoshida M, Takahata Y, Murakami T, Takenoshita S, Komori T, Nishimura R, Yoneda T: Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2. Communications Biology 4(1) 326, 2021. DOI:10.1038/s42003-021-01848-1

2020年

Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Von Der Mark K, Sakane C, Kaneko H, Komori T: Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLOS Genetics 16(11) e1009169 – e1009169 2020.

Komori T: Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle. Int J Mol Sci. 21(20) 7513-7513 2020.

Moriishi T, Komori T : Lack of reproducibility in osteocalcin-deficient mice. PLoS Genet.16(6) e1008939
2020.

Komori T: Molecular Processes in Chondrocyte Biology. Int J Mol Sci. 21(11)4161-4161 2020.

Komori T: What is the function of osteocalcin? J Oral Biosci 62(3)223-227, 2020.

Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, Miyazaki T, Wenguang L, Fukuyama R, Yuying W, Komori H, Qin X, Amizuka N, Komori T： Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. PLOS Genet. 16(5)e1008586-e1008586 ,2020. DOI: 10.1371/journal.pgen.1008586

Jiang Q, Qin X, Yoshida CA, Komori H, Yamana K, Ohba S, Hojo H, Croix BS, Kawata-Matsuura V, Komori T:
Antxr1,which is a target of Runx2, regulates chondrocyte proliferation and apoptosis. Int J Mol Sci. 21(7) 2425 2020. DOI: 10.3390/ijms 21072425

Kawata Matsuura V, Yoshida CA, Komori H, Sakane C, Yamana K, Jiang Q, Komori T: Expression of a Constitutively Active From of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice. Int J Mol Sci. 21(8) 2682 2020.
DOI: 10.3390/ijms 21082682

Komori T: Molecular Mechanism of Runx2-Dependent Bone Development. Mol Cells. 43(2)168-175, 2020.
DOI: 10.14348/molcells.2019.0244

Hirose K, Ishimoto T, Usami Y, Sato S, Oya K, Nakano T, Komori T, Toyosawa S: Overexpression of Fam20C in osteoblast in vivo leads to increased cortical bone formation and osteoclastic bone resorption. Bone 115414 2020.

2019年

Komori T: Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2, Int J Mol Sci. 20(7): 1694, 2019. DOI: 10.3390/ijms20071694

Qin X, Jiang Q, Miyazaki T, Komori T: Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt, and Pthlh signaling pathway gene expression in suture mesenchymal cells. Hum Mol Genet. 28(6):896-911, 2019. DOI: 10.1093/hmg/ddy386

Nakatomi C, Nakatomi M, Matsubara T, Komori T, Doi-Inoue T, Ishimaru N, Weih F, Iwamoto T, Masuda M, Kokabu S, Jimi E: Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification. Bone. 121:29-41, 2019. DOI: 10.1016/j.bone.2019.01.002

2018年

Mitoma K, Matsunaga S, Kitamura K, Nakamura T, Saito A, Komori T, Muramatsu T, Yamaguchi A: Sphenoid bone hypoplasia is a skeletal phenotype of cleidocranial dysplasia in a mouse model and patients. Bone. 120:176-186, 2019. DOI: 10.1016/j.bone.2018.10.028

Saito K, Takahashi K, Huang B, Asahara M, Kiso H, Togo Y, Tsukamoto H, Mishima S, Nagata M, Iida M, Tokita Y, Asai M, Shimizu A, Komori T, Harada H, MacDougall M, Sugai M & Bessho K: Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb−/−Runx2+/− Murine Incisors. Sci Rep. 8(1):5169, 2018.
DOI: 10.1038/s41598-018-23515-y

Miyazaki T, Baba T.T, Mori M, Komori T: Collapsin response mediator protein 1, a novel marker protein for differentiated odontoblasts. Acta Histochem Cytochem. 20; 51(6): 185-190. 2018. DOI: 10.1267/ahc.18030

Kawane T, Qin X, Jiang Q, Miyazaki T, Komori H, Yoshida CA, Matsuura-Kawata VKDS, Sakane C, Matsuo Y, Nagai K, Maeno T, Date Y, Nishimura R, Komori T: Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3. Sci Rep. 10;8(1):13551, 2018 Sep.
DOI: 10.1038/s41598-018-31853-0

Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukait T, Kaneko T, Miyazaki T, Latz E, Hara Y: Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells. J Periodontal Res. 53(3):353-361, 2018 Jun. DOI: 10.1111/jre.12520.

Komori T: Runx2, an inducer of osteoblast and chondrocyte differentiation. Histochem Cell Biol. 149(4):313-323, 2018 Apr. DOI: 10.1007/s00418-018-1640-6.

2017年

Yang M, Arai A, Udagawa N, Hiraga T, Lijuan Z, Ito S, Komori T, Moriishi T, Matsuo K, Shimoda K, Zahalka AH, Kobayashi Y, Takahashi N, Mizoguchi T: Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy. Sci Rep. 2017 Jul 10;7(1):4928.
DOI: 10.1038/s41598-017-05401-1.

Miyazaki T, Inoue M, Baba T, Komori T: Overexpression of Sp7 in odontoblasts results in dentinogenesis imperfecta due to the inhibition of odontoblast maturation. J Oral Biosci. 59(2)113-120, 2017 May.
DOI: 10.1016/j.job.2017.03.003

Oya K, Ishida K, Nishida T, Sato S, Kishino M, Hirose K, Ogawa Y, Ikebe K, Takeshige F, Yasuda H, Komori T, Toyosawa S: Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization. Histochem Cell Biol. 2017 Mar; 147(3):341-351.
DOI: 10.1007/s00418-016-1490-z

Komori T: Roles of Runx2 in skeletal development. Adv Exp Med Biol. 962:83-93, 2017 Mar.
DOI: 10.1007/978-981-10-3233-2_6

2016年

Komori T: Cell Death in Chondrocytes, Osteoblasts, and Osteocytes. Int J Mol Sci. 2016 Nov, 17(12): E2045.
DOI: 10.3390/ijms17122045

Komori T: Glucocorticoid signaling and bone biology. Horm Metab Res. 48(11):755-763, 2016 Nov.
DOI: 10.1055/s-0042-110571

Togo Y, Takahashi K, Saito K, Kiso H, Tsukamoto H, Huang B, Yanagita M, Sugai M, Harada H, Komori T, Shimizu A, MacDougall M, Bessho K: Antagonistic functions of USAG-1 and RUNX2 during tooth development. PLoS One 11(8): e0161067, 2016 Aug. DOI: 10.1371/journal.pone.0161067

Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T: Overexpression of BCLXL in osteoblasts inhibits osteoblast apoptosis and increases bone volume and strength. J Bone Miner Res. 31(7):1366-80, 2016 jul. DOI: 10.1002/jbmr.2808

Jiang Q, Qin X, Kawane T, Matsuo Y, Taniuchi I, Komori H, Ito K, Izumi S, Komori T: Cbfb2 isoform dominates more potent Cbfb1 and is required for skeletal development. J Bone Miner Res. 31(7):1391-404, 2016 jul.
DOI: 10.1002/jbmr.2814

Nakamura S, Horie M, Daidoji T, Honda T, Yasugi M, Kuno A, Komori T, Okuzaki D, Narimatsu H, Nakaya T, Tomonaga K: Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication. J Virol. 90(4):1788-801, 2016 Feb. DOI: 10.1128/JVI.02246-15

2015年

Miyazaki T, Baba T, Mori M, Moriishi T, Komori T: Microtubule-associated protein tau (Mapt) is expressed in terminally differentiated odontoblasts and severely down-regulated in morphologically disturbed odontoblasts of Runx2 transgenic mice. Cell Tissue Res. 361(2):457-66, 2015 Aug.
DOI: 10.1007/s00441-015-2135-6

Komori T: Animal models for osteoporosis. Eur J Pharmacol. 759:287-94, 2015 jul.
DOI: 10.1016/j.ejphar.2015.03.028

Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T: Cbfb regulates bone development by stabilizing Runx family proteins. J Bone Miner Res. 30(4):706-14, 2015 Apr. DOI: 10.1002/jbmr.2379

Nakamura T, Naruse M, Chiba Y, Komori T, Sasaki K, Iwamoto M, Fukumoto S: Novel hedgehog agonists promote osteoblast differentiation in mesenchymal stem cells. J Cell Physiol. 230(4):922-9, 2015 Apr.
DOI: 10.1002/jcp.24823

Komori T: The functions of Runx family transcription factors and Cbfb in skeletal development. Oral sci.int. 12(1):1-4, 2015 Jan. DOI: 10.1016/S1348-8643(14)00032-9

Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC: Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi. Am J Pathol. 185(2):305-13, 2015 Feb.DOI: 10.1016/j.ajpath.2014.10.011

2014年

Yoshida CA, Kawane T, Moriishi T, Purushothaman A, Miyazaki T, Komori H, Mori M, Qin X, Hashimoto A, Sugahara K, Yamana K, Takada K, Komori T: Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin type O-glycans and reduction of glycosaminoglycans. J Biol Chem. 289(38):26584-96, 2014. DOI: 10.1074/jbc.M114.555987

Komori T: A review of the differing roles of dead and live osteocytes. Journal of Oral Biosciences. 56(3):101-104, 2014. DOI: 10.1016/j.job.2014.05.001

Komori T: Mouse Models for the Evaluation of Osteocyte Functions. J Bone Metab. 21(1):55-60, 2014.
DOI: 10.11005/jbm.2014.21.1.55

Kawane T, Komori H, Liu W, Moriishi T, Miyazaki T, Mori M, Matsuo Y, Takada Y, Izumi S, Jiang Q, Nishimura R, Kawai Y, Komori T: Dlx5 and Mef2 Regulate a novel Runx2 enhancer for osteoblast-specific expression. J Bone Miner Res. 29(9):1960-1969, 2014. DOI: 10.1002/jbmr.2240

Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T: Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation. PLoS One. 9(1):e86629. 2014.
DOI: 10.1371/journal.pone.0086629

Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T: Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum Mol Genet. 23(11):2953-67, 2014. DOI: 10.1093/hmg/ddu007

Ito K, Maruyama Z, Sakai A, Izumi S, Moriishi T, Yoshida CA, Miyazaki T, Komori H, Takada K, Kawaguchi H, Komori T: Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53dependent apoptosis without enhancing proliferation. Oncogene. 33(14):1862-71, 2014.
DOI: 10.1038/onc.2013.130

2013年

Shi X, Deepak V, Wang L, Ba X, Komori T, Zeng X, Liu W: Thrombospondin-1 is a putative target gene of runx2 and runx3. Int J Mol Sci. 14(7):14321-32, 2013.

Yoon WJ, Islam R, Cho YD, Woo KM, Baek JH, Uchida T, Komori T, van Wijnen A, Stein JL, Lian JB, Stein GS, Choi JY, Bae SC, Ryoo HM: Pin1-mediated Runx2 modification is critical for skeletal development. J Cell Physiol. 228(12):2377-85, 2013.

Sato S, Hashimoto J, Usami Y, Ohyama K, Isogai Y, Hagiwara Y, Maruyama N, Komori T, Kuroda T, Toyosawa S: Novel sandwich ELISAs for rat DMP1: age-related decrease of circulatory DMP1 levels in male rats. Bone. 57(2):429-436, 2013.

Komori T: Regulation of Rb family proteins by Cdk6/Ccnd1 in growth plates. Cell Cycle. 12(14):2161-2162, 2013.

Komori T: Functions of the osteocyte network in the regulation of bone mass. Cell Tissue Res. 352(2):191-198, 2013.

Watanabe T, Oyama T, Asada M, Harada D, Ito Y, Inagawa M, Suzuki Y, Sugano S, Katsube K, Karsenty G, Komori T, Kitagawa M, Asahara H: MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLos Genet. 9(1):e1003132. 2013.

Miyazaki T, Mori M, Yoshida CA, Ito C, Yamatoya K, Moriishi T, Kawai Y, Komori H, Kawane T, Izumi S, Toshimori K, Komori T: Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia. Histochem Cell Biol. 139(2):339-354, 2013.

2012年

Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M: In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues. Sci Rep. 2:642, 2012.

Kagawa R, Kishino M, Sato S, Ishida K, Ogawa Y, Ikebe K, Oya K, Ishimoto T, Nakano T, Maeda Y, Komori T, Toyosawa S: Chronological histological changes during bone regeneration on a non-crosslinked atelocollagen matrix. J Bone Miner Metab. 30(6):638-650, 2012.

Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T: Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PLoS One. 7(6):e40143. 2012.

Moriishi T, Komori T: Osteocyte- The instructive role in bone mass regulation- Regulation of bone mass by osteocyte network. Clin Calcium. 22(5):705-712, 2012.

Tanaka K, Inoue Y, Hendy GN, Canaff L, Katagiri T, Kitazawa R, Komori T, Sugimoto T, Seino S, Kaji H: Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells. Bone. 51(1):158-167, 2012.

Masuyama R, Mizuno A, Komori H, Kajiya H, Uekawa A, Kitaura H, Okabe K, Ohyama K, Komori T: Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass. J Bone Miner Res. 27(8):1708-1721, 2012.

Mizuhashi K, Kanamoto T, Ito M, Moriishi T, Muranishi Y, Omori Y, Terada K, Komori T, Furukawa T: OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis. Dev Growth Differ. 54(4):474-480, 2012.

Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, Moriishi T, Kawaguchi H, Takada K, Komori T: SP7 inhibits osteoblast differentiation at a late stage in mice. PLoS One. 7(3):e32364. 2012.

Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T: Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis. Bone. 50(1):409-419, 2012.

Toyosawa S, Sato S, Kagawa R, Komori T, Ikebe K: Role of SIBLINGs on matrix mineralization: Focus on dentin matrix protein 1 (DMP1). J Oral Biosci. 54(1):30-36, 2012.

2011年

Moriishi T, Maruyama Z, Fukuyama R, Ito M, Miyazaki T, Kitaura H, Ohnishi H, Furuichi T, Kawai Y, Masuyama R, Komori H, Takada K, Kawaguchi H, Komori T: Overexpression of bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PLoS One. 6(11):e27487, 2011.

Maeno T, Moriishi T, Yoshida CA, Komori H, Kanatani N, Izumi S, Takaoka K, Komori T. Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone. 49(4):673-682, 2011.

Cao L, Moriishi T, Miyazaki T, Iimura T, Hamagaki M, Nakane A, Tamamura Y, Komori T, Yamaguchi A: Comparative morphology of the osteocyte lacunocanalicular system in various vertebrates. J Bone Miner Metab. 29(6):662-670, 2011.

Hisa I, Inoue Y, Hendy GN, Canaff L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S, Kaji H: Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. J Biol Chem. 286(11):9787-9796, 2011.

Ann EJ, Kim HY, Choi YH, Kim MY, Mo JS, Jung J, Yoon JH, Kim SM, Moon JS, Seo MS, Hong JA, Jang WG, Shore P, Komori T, Koh JT, and Park HS: Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation. J Bone Miner Res. 26(2):317-330, 2011.

Komori T: Signaling networks in RUNX2-dependent bone development. J Cell Biochem. 112(3):750-755, 2011.

Mikasa M, Rokutanda S, Komori H, Ito K, Tsang YS, Date Y, Yoshida CA, Komori T: Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation. J Bone Miner Metab. 29(3):291-299, 2011.

2004－2010年

Watanabe K, Sugai M, Nambu Y, Osato M, Hayashi T, Kawaguchi M, Komori T, Ito Y, Shimizu A: Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF-{beta}1 and Retinoic Acid Signaling. J Immunol. 184(6):2785-2792, 2010.

Komori T: Regulation of osteoblast differentiation by runx2. Adv Exp Med Biol. 658:43-49, 2010.

Komori T: Regulation of osteoblast and odontoblast differentiation by Runx2. J Oral Biosci. 52(1):22-25, 2010.

Komori T: Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res. 339(1):189-195, 2010.

Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Komori H, Liu W, Mizuno A Komori T: Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol. 328(1):78-93, 2009.

Sakamoto J, Origuchi T, Okita M, Nakano J, Kato K, Yoshimura T, Izumi S, Komori T, Nakamura H, Ida H, Kawakami A, Eguchi K: Immobilization-induced cartilage degeneration mediated through expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and chondromodulin-I. Connect Tissue Res. 50(1):37-45, 2009.

Kuo YH, Zaidi SK, Gornostaeva S, Komori T, Stein GS, Castilla LH: Runx2 induces acute myeloid leukemia in cooperation with Cbf{beta}-SMMHC in mice. Blood. 113(14):3323-3332, 2009.

Miyazaki T, Kanatani N, Rokutanda S, Yoshida C, Toyosawa S, Nakamura R, Takada S, Komori T: Inhibition of terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice. Arch Histol Cytol. 71:131-146, 2008.

Takeda Y, He P, Tachibana I, Zhou B, Miyado K, Kaneko H, Suzuki M, Minami S, Iwasaki T, Goya S, Kijima T, Kumagai T, Yoshida M, Osaki T, Komori T, Mekada E, Kawase I: Double deficiency of tetraspanins CD9 and CD81 Alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. J Biol Chem. 283(38):26089-97, 2008.

Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, Iso T, Komori T, Arai M, Kurabayashi M: Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. Mol Cell Biol. 28(3):1147-60, 2008.

Komori T: Regulation of bone development and maintenance by Runx2. Front Biosci. 13:898-903, 2008.

Fukuoka H, Shibata S, Suda N, Yamashita Y, Komori T:Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice. J Anat. 211(1):8-15, 2007.

Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura H, Nakamura K, Fujita T, Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, Komori T: Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn. 236(7):1876-1890, 2007.

Iwamoto M, Tamamura Y, Koyama E, Komori T, Takeshita N, Williams JA, Nakamura T, Enomoto-Iwamoto M, Pacifici M. Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol. 305(1):40-51, 2007.

Toyosawa S, Yuki M, Kishino M, Ogawa Y, Ueda T, Murakami S, Konishi E, Iida S, Kogo M, Komori T, Tomita Y: Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. Mod Pathol. 20(3):389-396, 2007.

Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M: Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J. 26(1):184-196, 2007.

Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A: BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol. 211(3):728-735, 2007.

Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung UI, Kawaguchi H. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum. 54(8):2462-2470, 2006.

Kanatani N, Fujita T, Fukuyama R, Liu W, Yoshida CA, Moriishi T, Yamana K, Miyazaki T, Toyosawa S, Komori T. Cbfb regulates Runx2 function isoform-dependently in postnatal bone development. Dev Biol. 296(1):48-61, 2006.

Salingcarnboriboon R, Tsuji K, Komori T, Nakashima K, Ezura Y, Noda M: Runx2 is a Target of Mechanical Unloading to Alter Osteoblastic Activity and Bone Formation in Vivo. Endocrinology. 147(5):2296-2305, 2006.

Komori T: Regulation of osteoblast differentiation by transcription factors. J Cell Biochem. 99(5):1233-1239, 2006.

Goto T, Matsui Y, Fernandes RJ, Hanson DA, Kubo T, Yukata K, Michigami T, Komori T, Fujita T, Yang L, Eyre DR, Yasui N: Sp1 family of transcription factors regulates the human a2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res. 21(5):661-673, 2006.

Yoshida CA, Komori T: Role of Runx proteins in chondrogenesis. Crit Rev Eukaryot Gene Expr. 15(3):243-254, 2005.

Yamaai T, Nakanishi T, Asano M, Nawachi K, Yoshimichi G, Ohyama K, Komori T, Sugimoto T, Takigawa M:
Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development. J Bone Miner Metab. 23(4):280-288, 2005.

Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M: Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 280(19):19185-19195, 2005.

Choi KY, Kim HJ, Lee MH, Kwon TG, Nah HD, Furuichi T, Komori T, Nam SH, Kim YJ, Kim HJ, Ryoo HM: Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development. Dev Dyn. 233(1):115-121, 2005.

Komori T: Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem. 95(3):445–453, 2005.

Komori T: The roles of Runx family and Cbfb in skeletal development. Dentistry in Japan 41:3-7, 2005.

Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung U, Nakamura K, Okayama H, Kawaguchi H: Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5. J Cell Physiol. 204(3):927-933, 2005.

Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H: Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 19(5):536-541, 2005.

Fujita T, Fukuyama R, Enomoto H, Komori T: Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2. J Cell Biochem. 93(2):374-383, 2004.

Sowa H, Kaji H, Hendy GN, Canaff L, Komori T, Sugimoto T, Chihara K: Menin is required for bone morphogenetic protein 2- and transforming growth factor β-regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem. 279(39):40267-40275, 2004.

Tsuji K, Komori T, Noda M: Aged mice require full transcription factor, Runx2/Cbfa1, gene dosage for cancellous bone regeneration after bone marrow ablation. J Bone Miner Res. 19(9):1481-1489, 2004.

Ichida F, Nishimura R, Hata K, Matsubara T, Ikeda F, Hisada K, Yatani H, Cao X, Komori T, Yamaguchi A, Yoneda T: Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem. 279(32):34015-34022, 2004.

Shibata S, Suda N, Yoda S, Fukuoka H, Ohyama K, Yamashita Y, Komori T: Runx2-deficient mice lack mandibular condylar cartilage and have deformed Meckel's cartilage. Anat Embryol. 208(4):273-280, 2004.

Toyosawa S, Kanatani N, Shintani S, Kobata M, Yuki M, Kishino M, Ijuhin N Komori T: Expression of dentin matrix protein 1 (DMP1) during fracture healing. Bone 35(2):553-561, 2004.

Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida CA, Koida M, Ogita K, Komori T: Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol. 166(1):85-95, 2004.

Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T: Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 18(8):952-963, 2004.

Chung CR, Tsuji K, Nifuji A, Komori T, Soma K, Noda M: Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice. J Med Dent Sci. 51(1):105-113, 2004.

Yoda S, Suda N, Kitahara Y, Komori T, Ohyama K: Delayed tooth eruption and suppressed osteoclast number in the eruption pathway of heterozygous Runx2/Cbfa1 knockout mice. Arch Oral Biol. 49(6):435-442, 2004.

Kadowaki A, Tsukazaki T, Hirata K, Shibata Y, Okubo Y, Bessho K, Komori T, Yoshida N, Yamaguchi A: Isolation and characterization of a mesenchymal cell line that differentiates into osteoblasts in response to BMP-2 from calvariae of GFP transgenic mice. Bone 34(6):993-1003, 2004.

Shimoaka T, Kamekura S, Chikuda H, Hoshi K, Chung UI, Akune T, Maruyama Z, Komori T, Matsumoto M, Ogawa W, Terauchi Y, Kadowaki T, Nakamura K, Kawaguchi H: Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem. 279(15):15314-15322, 2004.

Ichikawa Y, Sumi M, Ohwatari N, Komori T, Sumi T, Shibata H, Furuichi T, Yamaguchi A, Nakamura T: Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development: comparison of MR imaging and histological findings. Bone 34(4):619-628, 2004.

Toyosawa S, Tomita Y, Kishino M, Hashimoto J, Ueda T, Tsujimura T, Aozasa K, Ijuhin N, Komori T: Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia. Mod Pathol. 17(5):573-578, 2004.

Fukuyama R, Fujita T, Azuma Y, Hirano A, Nakamuta H, Koida M, Komori T: Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. Biochem Biophys Res Commun. 315(3):636-642, 2004.

Toyosawa S, Okabayashi K, Komori T, Ijuhin N: mRNA expression and protein localization of dentin matrix protein 1 during dental root formation. Bone 34(1):124-133, 2004.

Enomoto H, Furuichi T, Zanma A, Yamana K, Yoshida C, Sumitani S, Yamamoto H, Enomoto-Iwamoto M, Iwamoto M, Komori T: Runx2 deficiency in chondrocytes causes adipogenic changes in vitro. J Cell Sci. 117(Pt3): 417-425, 2004.